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dc.contributor.authorBronikowski, Anne M.
dc.contributor.authorMeisel, Richard P.
dc.contributor.authorBiga, Peggy R.
dc.contributor.authorWalters, James R.
dc.contributor.authorMank, Judith E.
dc.contributor.authorLarschan, Erica
dc.contributor.authorWilkinson, Gerald S.
dc.contributor.authorValenzuela, Nicole
dc.contributor.authorConard, Ashley Mae
dc.contributor.authorde Magalhães, João Pedro
dc.contributor.authorDuan, Jingyue (Ellie)
dc.contributor.authorElias, Amy E.
dc.contributor.authorGamble, Tony
dc.contributor.authorGraze, Rita M.
dc.contributor.authorGribble, Kristin E.
dc.contributor.authorKreiling, Jill A.
dc.contributor.authorRiddle, Nicole C.
dc.identifier.citationBronikowski, A. M., Meisel, R. P., Biga, P. R., Walters, J. R., Mank, J. E., Larschan, E., Wilkinson, G. S., Valenzuela, N., Conard, A. M., de Magalhães, J. P., Duan, J. E., Elias, A. E., Gamble, T., Graze, R. M., Gribble, K. E., Kreiling, J. A., & Riddle, N. C. (2022). Sex-specific aging in animals: Perspective and future directions. Aging cell, 21(2), e13542.
dc.description.abstractSex differences in aging occur in many animal species, and they include sex differences in lifespan, in the onset and progression of age‐associated decline, and in physiological and molecular markers of aging. Sex differences in aging vary greatly across the animal kingdom. For example, there are species with longer‐lived females, species where males live longer, and species lacking sex differences in lifespan. The underlying causes of sex differences in aging remain mostly unknown. Currently, we do not understand the molecular drivers of sex differences in aging, or whether they are related to the accepted hallmarks or pillars of aging or linked to other well‐characterized processes. In particular, understanding the role of sex‐determination mechanisms and sex differences in aging is relatively understudied. Here, we take a comparative, interdisciplinary approach to explore various hypotheses about how sex differences in aging arise. We discuss genomic, morphological, and environmental differences between the sexes and how these relate to sex differences in aging. Finally, we present some suggestions for future research in this area and provide recommendations for promising experimental designs.en_US
dc.publisherWiley Open Accessen_US
dc.rights© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License.en_US
dc.subjectComparative biologyen_US
dc.subjectSex differencesen_US
dc.titleSex-specific aging in animals: Perspective and future directionsen_US
kusw.kuauthorWalters, James R.
kusw.kudepartmentEcology and Evolutionary Biologyen_US
kusw.oanotesPer Sherpa Romeo 05/03/2022:

Aging Cell [Open panel below]Publication Information TitleAging Cell [English] ISSNs Print: 1474-9718 Electronic: 1474-9726 URL Publishers Anatomical Society of Great Britain and Ireland [Associate Organisation] Wiley Open Access [Commercial Publisher] DOAJ Listing Requires APCYes [Data provided by DOAJ] [Open panel below]Publisher Policy Open Access pathways permitted by this journal's policy are listed below by article version. Click on a pathway for a more detailed view.

Published Version NoneCC BYPMC Any Website, Journal Website, +3 OA PublishingThis pathway includes Open Access publishing EmbargoNo Embargo LicenceCC BY Copyright OwnerAuthors Publisher DepositPubMed Central Location Any Website Institutional Repository Named Repository (PubMed Central) Subject Repository Journal Website Conditions Hosting site must incorporate publisher-supplied amendments or retractions issued Published source must be acknowledged Must link to published article with DOI
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kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as: © 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License.