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Sex-specific aging in animals: Perspective and future directions

dc.contributor.authorBronikowski, Anne M.
dc.contributor.authorMeisel, Richard P.
dc.contributor.authorBiga, Peggy R.
dc.contributor.authorWalters, James R.
dc.contributor.authorMank, Judith E.
dc.contributor.authorLarschan, Erica
dc.contributor.authorWilkinson, Gerald S.
dc.contributor.authorValenzuela, Nicole
dc.contributor.authorConard, Ashley Mae
dc.contributor.authorde Magalhães, João Pedro
dc.contributor.authorDuan, Jingyue (Ellie)
dc.contributor.authorElias, Amy E.
dc.contributor.authorGamble, Tony
dc.contributor.authorGraze, Rita M.
dc.contributor.authorGribble, Kristin E.
dc.contributor.authorKreiling, Jill A.
dc.contributor.authorRiddle, Nicole C.
dc.date.accessioned2022-05-03T16:27:21Z
dc.date.available2022-05-03T16:27:21Z
dc.date.issued2022-01-23
dc.identifier.citationBronikowski, A. M., Meisel, R. P., Biga, P. R., Walters, J. R., Mank, J. E., Larschan, E., Wilkinson, G. S., Valenzuela, N., Conard, A. M., de Magalhães, J. P., Duan, J. E., Elias, A. E., Gamble, T., Graze, R. M., Gribble, K. E., Kreiling, J. A., & Riddle, N. C. (2022). Sex-specific aging in animals: Perspective and future directions. Aging cell, 21(2), e13542. https://doi.org/10.1111/acel.13542en_US
dc.identifier.urihttp://hdl.handle.net/1808/32745
dc.description.abstractSex differences in aging occur in many animal species, and they include sex differences in lifespan, in the onset and progression of age‐associated decline, and in physiological and molecular markers of aging. Sex differences in aging vary greatly across the animal kingdom. For example, there are species with longer‐lived females, species where males live longer, and species lacking sex differences in lifespan. The underlying causes of sex differences in aging remain mostly unknown. Currently, we do not understand the molecular drivers of sex differences in aging, or whether they are related to the accepted hallmarks or pillars of aging or linked to other well‐characterized processes. In particular, understanding the role of sex‐determination mechanisms and sex differences in aging is relatively understudied. Here, we take a comparative, interdisciplinary approach to explore various hypotheses about how sex differences in aging arise. We discuss genomic, morphological, and environmental differences between the sexes and how these relate to sex differences in aging. Finally, we present some suggestions for future research in this area and provide recommendations for promising experimental designs.en_US
dc.publisherWiley Open Accessen_US
dc.rights© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectAgingen_US
dc.subjectComparative biologyen_US
dc.subjectLifespanen_US
dc.subjectMortalityen_US
dc.subjectSex differencesen_US
dc.titleSex-specific aging in animals: Perspective and future directionsen_US
dc.typeArticleen_US
kusw.kuauthorWalters, James R.
kusw.kudepartmentEcology and Evolutionary Biologyen_US
dc.identifier.doi10.1111/acel.13542en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-6432-298Xen_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-7362-9307en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-0540-291Xen_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-6340-995Xen_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-2450-513Xen_US
dc.identifier.orcidhttps://orcid.org/ 0000-0003-2484-4921en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-7799-8444en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0003-1148-631Xen_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-4143-6180en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-6363-2465en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-6416-2250en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-9013-6240en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-0204-8003en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0001-9872-109Xen_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-8781-9523en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0003-4440-2039en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0003-1827-9145en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC8844111en_US
dc.rights.accessrightsopenAccessen_US


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© 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as: © 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License.