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dc.contributor.authorWolfe, Michael S.
dc.date.accessioned2022-01-11T17:08:25Z
dc.date.available2022-01-11T17:08:25Z
dc.date.issued2021-01-13
dc.identifier.citationWolfe, M.S. Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease. Molecules 2021, 26, 388. https://doi.org/10.3390/molecules26020388en_US
dc.identifier.urihttp://hdl.handle.net/1808/32388
dc.description.abstractThe membrane-embedded γ-secretase complex carries out hydrolysis within the lipid bilayer in proteolyzing nearly 150 different membrane protein substrates. Among these substrates, the amyloid precursor protein (APP) has been the most studied, as generation of aggregation-prone amyloid β-protein (Aβ) is a defining feature of Alzheimer’s disease (AD). Mutations in APP and in presenilin, the catalytic component of γ-secretase, cause familial AD, strong evidence for a pathogenic role of Aβ. Substrate-based chemical probes—synthetic peptides and peptidomimetics—have been critical to unraveling the complexity of γ-secretase, and small drug-like inhibitors and modulators of γ-secretase activity have been essential for exploring the potential of the protease as a therapeutic target for Alzheimer’s disease. Such chemical probes and therapeutic prototypes will be reviewed here, with concluding commentary on the future directions in the study of this biologically important protease complex and the translation of basic findings into therapeutics.en_US
dc.publisherMDPIen_US
dc.rights© 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectProteaseen_US
dc.subjectAmyloiden_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectInhibitorsen_US
dc.subjectModulatorsen_US
dc.titleProbing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Diseaseen_US
dc.typeArticleen_US
kusw.kuauthorWolfe, Michael S.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.3390/molecules26020388en_US
dc.identifier.orcidhttps://orcid.org/ 0000-0002-5721-9092en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC7828430en_US
dc.rights.accessrightsopenAccessen_US


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© 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Except where otherwise noted, this item's license is described as: © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.