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Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease

dc.contributor.authorJia, Kun
dc.contributor.authorDu, Heng
dc.date.accessioned2022-01-06T18:50:01Z
dc.date.available2022-01-06T18:50:01Z
dc.date.issued2021-03-15
dc.identifier.citationJia, K.; Du, H. Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease. Cells 2021, 10, 649. https://doi.org/10.3390/cells10030649en_US
dc.identifier.urihttp://hdl.handle.net/1808/32353
dc.description.abstractAdvanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a mitochondrial hypothesis of brain aging and AD has been accentuated. Mitochondrial permeability transition pore (mPTP) is a mitochondrial response to intramitochondrial and intracellular stresses. mPTP overactivation has been implicated in mitochondrial dysfunction in aging and AD brains. This review summarizes the up-to-date progress in the study of mPTP in aging and AD and attempts to establish a link between brain aging and AD from a perspective of mPTP-mediated mitochondrial dysfunction.en_US
dc.publisherMDPIen_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectMitochondrial permeability transitionen_US
dc.subjectBrain agingen_US
dc.subjectAlzheimer’s diseaseen_US
dc.titleMitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Diseaseen_US
dc.typeArticleen_US
kusw.kuauthorJia, Kun
kusw.kuauthorDu, Heng
kusw.kudepartmentPharmacology and Toxicologyen_US
kusw.kudepartmentHiguchi Biosciences Centeren_US
dc.identifier.doi10.3390/cells10030649en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC8001058en_US
dc.rights.accessrightsopenAccessen_US


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© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
Except where otherwise noted, this item's license is described as: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.