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Lithium perchlorate-, acetic anhydride-, and triphenylphosphine-assisted multicomponent syntheses of 4-unsubstituted 2,5-dioxooctahydroquinoline-3-carboxylates and 3-carbonitriles
| dc.contributor.author | Gu, Xingxian | |
| dc.contributor.author | Georg, Gunda I. | |
| dc.date.accessioned | 2021-10-05T20:33:18Z | |
| dc.date.available | 2021-10-05T20:33:18Z | |
| dc.date.issued | 2013-09-05 | |
| dc.identifier.citation | Gu, X., & Georg, G. I. (2013). Lithium Perchlorate-, Acetic Anhydride-, and Triphenylphosphine-assisted Multicomponent Syntheses of 4-Unsubstituted 2,5-Dioxooctahydroquinoline-3-carboxylates and 3-carbonitriles. Tetrahedron, 69(45), 9406–9416. doi:10.1016/j.tet.2013.08.081 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/31911 | |
| dc.description.abstract | Lithium perchlorate and acetic anhydride were the key additives for the multi-component reaction between 3-aminocyclohex-2-enones, formaldehyde, and malonates yielding adducts that were annulated under acidic conditions to afford bicyclic 2,5-dioxooctahydroquinoline-3-carboxylates. When methyl cyanoacetate was subjected to the same reaction conditions in the presence of a catalytic amount of triphenylphosphine, the bicyclic 2,5-dioxooctahydroquinoline-3-carbonitriles were obtained in a one-flask reaction. | en_US |
| dc.publisher | Elsevier | en_US |
| dc.rights | © 2013 Elsevier Ltd. This work is licensed under a Creative Commons Attribution Non-Commercial-No Derivatives 4.0 International License. | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.title | Lithium perchlorate-, acetic anhydride-, and triphenylphosphine-assisted multicomponent syntheses of 4-unsubstituted 2,5-dioxooctahydroquinoline-3-carboxylates and 3-carbonitriles | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Gu, Xingxian | |
| kusw.kudepartment | Department of Medicinal Chemistry | en_US |
| dc.identifier.doi | 10.1016/j.tet.2013.08.081 | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC6884338 | en_US |
| dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: © 2013 Elsevier Ltd. This work is licensed under a Creative Commons Attribution Non-Commercial-No Derivatives 4.0 International License.
