DEVELOPMENT, CONSTRUCTION AND VALIDATION OF A TWO-COMPARTMENT ANALYTICAL INSTRUMENT FOR USE AS AN ALTERNATIVE DISSOLUTION METHOD FOR PHARMACEUTICAL TESTING

Kretz, Jonathan

dc.contributor.advisor	Krise, Jeffrey
dc.contributor.advisor	Chung, John
dc.contributor.author	Kretz, Jonathan
dc.date.accessioned	2021-04-25T20:24:01Z
dc.date.available	2021-04-25T20:24:01Z
dc.date.issued	2020-08-31
dc.date.submitted	2020
dc.identifier.other	http://dissertations.umi.com/ku:17374
dc.identifier.uri	http://hdl.handle.net/1808/31616
dc.description.abstract	The purpose of this research was to develop, construct and validate a two-compartment dissolution testing instrument as an alternative test methodology to the current standard USP apparatus II system. The current USP apparatus II system was developed in the 1970’s and has known defects in its design related to fluid dynamics and bio relevance. This two-compartment dissolution instrument eliminates the issues of fluid dynamic mixing, use of biorelevant media levels and provides clinically relevant data. The two-compartment dissolution instrument was tested in conjunction with GastroPlus simulations to mimic a human model with drug absorbance set to zero. This instrument was able to produce similar gastric and duodenum amount recovery profiles from GastroPlus for the two compounds tested.
dc.format.extent	74 pages
dc.language.iso	en
dc.publisher	University of Kansas
dc.rights	Copyright held by the author.
dc.subject	Pharmaceutical sciences
dc.subject	Comparison to GastroPlus
dc.subject	Dissolution
dc.subject	Dissolution Fluid Dynamics
dc.subject	Dissolution Media Volume
dc.subject	Dissolution Multi Compartment
dc.subject	Dissolution Transfer Rate
dc.title	DEVELOPMENT, CONSTRUCTION AND VALIDATION OF A TWO-COMPARTMENT ANALYTICAL INSTRUMENT FOR USE AS AN ALTERNATIVE DISSOLUTION METHOD FOR PHARMACEUTICAL TESTING
dc.type	Thesis
dc.contributor.cmtemember	Hageman, Michael
dc.thesis.degreeDiscipline	Pharmaceutical Chemistry
dc.thesis.degreeLevel	M.S.
dc.rights.accessrights	openAccess

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