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dc.contributor.authorXie, Sheng-Xue
dc.contributor.authorBoone, Kyle
dc.contributor.authorVanOosten, Sarah Kay
dc.contributor.authorYuca, Esra
dc.contributor.authorSong, Linyong
dc.contributor.authorGe, Xueping
dc.contributor.authorYe, Qiang
dc.contributor.authorSpencer, Paulette
dc.contributor.authorTamerler, Candan
dc.identifier.citationXie, S.-X.; Boone, K.; VanOosten, S.K.; Yuca, E.; Song, L.; Ge, X.; Ye, Q.; Spencer, P.; Tamerler, C. Peptide Mediated Antimicrobial Dental Adhesive System. Appl. Sci. 2019, 9, 557.en_US
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractThe most common cause for dental composite failures is secondary caries due to invasive bacterial colonization of the adhesive/dentin (a/d) interface. Innate material weakness often lead to an insufficient seal between the adhesive and dentin. Consequently, bacterial by-products invade the porous a/d interface leading to material degradation and dental caries. Current approaches to achieve antibacterial properties in these materials continue to raise concerns regarding hypersensitivity and antibiotic resistance. Herein, we have developed a multi-faceted, bio-functionalized approach to overcome the vulnerability of such interfaces. An antimicrobial adhesive formulation was designed using a combination of antimicrobial peptide and a ε-polylysine resin system. Effector molecules boasting innate immunity are brought together with a biopolymer offering a two-fold biomimetic design approach. The selection of ε-polylysine was inspired due to its non-toxic nature and common use as food preservative. Biomolecular characterization and functional activity of our engineered dental adhesive formulation were assessed and the combinatorial formulation demonstrated significant antimicrobial activity against Streptococcus mutans. Our antimicrobial peptide-hydrophilic adhesive hybrid system design offers advanced, biofunctional properties at the critical a/d interface.en_US
dc.rights© 2019 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.subjectAntimicrobial peptideen_US
dc.subjectAdhesive formulationen_US
dc.subjectHybrid interfaceen_US
dc.subjectDental compositesen_US
dc.titlePeptide Mediated Antimicrobial Dental Adhesive Systemen_US
kusw.kuauthorXie, Sheng-Xue
kusw.kuauthorBoone, Kyle
kusw.kuauthorVanOosten, Sarah Kay
kusw.kuauthorYuca, Esra
kusw.kuauthorSong, Linyong
kusw.kuauthorGe, Xueping
kusw.kuauthorYe, Qiang
kusw.kuauthorSpencer, Paulette
kusw.kuauthorTamerler, Candan
kusw.kudepartmentInstitute for Bioengineering Researchen_US
kusw.kudepartmentMechanical Engineeringen_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Except where otherwise noted, this item's license is described as: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.