dc.contributor.author | Agusto, Folashade B. | |
dc.contributor.author | Kim, Soyeon | |
dc.date.accessioned | 2020-12-22T19:38:15Z | |
dc.date.available | 2020-12-22T19:38:15Z | |
dc.date.issued | 2019-06-17 | |
dc.identifier.citation | Agusto, F.B.; Kim, S. Impact of Mobility on Methicillin-Resistant Staphylococcus aureus among Injection Drug Users. Antibiotics 2019, 8, 81. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/30992 | |
dc.description | This work is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
dc.description.abstract | In this study, we develop and present a deterministic model for the transmission dynamics of methicillin-resistant staphylococcus aureus (MRSA) among injection drug users. The model consists of non-injection drug users as well as low-and high-risk injection drug users (IDUs). The model further incorporates the movement of these individuals between large metro, suburban and rural areas. The model parameters were estimated by fitting the model to the 2008–2013 disease prevalence data for non-IDUs obtained from the Agency for Healthcare and Research and Quality (AHRQ), as well as the 2009–2013 Census Bureau data for the number of individuals migrating between three different counties in Kansas. Sensitivity analysis was implemented to determine the parameters with the most significant impact on the total number of infected individuals; the transmission probability, recovery rates, and positive behavioral change parameter for the subgroup have the most significant effect on the number of infected individuals. Furthermore, the sensitivity of the parameters in the different areas was the same when the areas are disconnected. When the areas are connected, the parameters in large-metro areas were the most sensitive, and the rural areas were least sensitive. The result shows that to effectively control the disease across the large metro, suburban and rural areas, it is best to focus on controlling both behavior and disease in the large metro area as this has a trickle-down effect to the other places. However, controlling behavior and disease at the same time in all the areas will lead to the elimination of the disease. | en_US |
dc.publisher | MDPI | en_US |
dc.rights | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | MRSA | en_US |
dc.subject | Injection drug users | en_US |
dc.subject | Mobility | en_US |
dc.subject | Sensitivity analysis | en_US |
dc.subject | Control strategies | en_US |
dc.title | Impact of Mobility on Methicillin-Resistant Staphylococcus aureus among Injection Drug Users | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Agusto, Folashade B. | |
kusw.kuauthor | Kim, Soyeon | |
kusw.kudepartment | Ecology and Evolutionary Biology | en_US |
kusw.kudepartment | Molecular Biosciences | en_US |
kusw.oanotes | Per Sherpa Romeo 12/22/2020:Antibiotics
[Open panel below]Publication Information
TitleAntibiotics [English]
ISSNsElectronic: 2079-6382
URLhttp://www.mdpi.com/journal/antibiotics
PublishersMDPI [Commercial Publisher]
DOAJ Listinghttps://doaj.org/toc/2079-6382
Requires APCYes [Data provided by DOAJ]
[Open panel below]Publisher Policy
Open Access pathways permitted by this journal's policy are listed below by article version. Click on a pathway for a more detailed view.Published Version
NoneCC BYPMC
Any Repository, Journal Website, +1
OA PublishingThis pathway includes Open Access publishing
EmbargoNo Embargo
LicenceCC BY 4.0
Copyright OwnerAuthors
Publisher DepositPubMed Central
Location
Any Repository
Named Repository (PubMed Central)
Journal Website
ConditionsPublished source must be acknowledged with citation
NotesAuthors are encouraged to submit their published articles to institutional repositories | en_US |
dc.identifier.doi | 10.3390/antibiotics8020081 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-6137-6480 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
kusw.proid | ID195410227200 | en_US |
dc.rights.accessrights | openAccess | en_US |