Selenium and the Methionine Sulfoxide Reductase System
| dc.contributor.author | Oien, Derek B. | |
| dc.contributor.author | Moskovitz, Jackob | |
| dc.date.accessioned | 2020-12-03T17:09:08Z | |
| dc.date.available | 2020-12-03T17:09:08Z | |
| dc.date.issued | 2009-07-01 | |
| dc.identifier.citation | Oien, D. B., & Moskovitz, J. (2009). Selenium and the methionine sulfoxide reductase system. Molecules (Basel, Switzerland), 14(7), 2337–2344. https://doi.org/10.3390/molecules14072337 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/30957 | |
| dc.description | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license | en_US |
| dc.description.abstract | Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA-/-), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA-/- mice are presented and discussed. | en_US |
| dc.publisher | MDPI | en_US |
| dc.rights | © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | en_US |
| dc.subject | Selenoprotein | en_US |
| dc.subject | Methionine sulfoxide | en_US |
| dc.subject | Oxidative stress | en_US |
| dc.subject | Antioxidants | en_US |
| dc.subject | Posttranslational modification | en_US |
| dc.title | Selenium and the Methionine Sulfoxide Reductase System | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Oien, Derek B. | |
| kusw.kuauthor | Moskovitz, Jackob | |
| kusw.kudepartment | Pharmacology and Toxicology | en_US |
| dc.identifier.doi | 10.3390/molecules14072337 | en_US |
| kusw.oaversion | Scholarly/refereed, publisher version | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC6254969 | en_US |
| dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
