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Selenium and the Methionine Sulfoxide Reductase System

dc.contributor.authorOien, Derek B.
dc.contributor.authorMoskovitz, Jackob
dc.date.accessioned2020-12-03T17:09:08Z
dc.date.available2020-12-03T17:09:08Z
dc.date.issued2009-07-01
dc.identifier.citationOien, D. B., & Moskovitz, J. (2009). Selenium and the methionine sulfoxide reductase system. Molecules (Basel, Switzerland), 14(7), 2337–2344. https://doi.org/10.3390/molecules14072337en_US
dc.identifier.urihttp://hdl.handle.net/1808/30957
dc.descriptionThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution licenseen_US
dc.description.abstractSelenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system that reduces methionine sulfoxide (MetO) to methionine comprises the selenoprotein MsrB (MsrB1) and the non-selenoprotein MsrA, which reduce the R- and the S- forms of MetO, respectively. The effects of a selenium deficient (SD) diet, which was administrated to wild type (WT) and MsrA knockout mice (MsrA-/-), on the expression and function of Msr-related proteins are examined and discussed. Additionally, new data about the levels of selenium in brain, liver, and kidneys of WT and MsrA-/- mice are presented and discussed.en_US
dc.publisherMDPIen_US
dc.rights© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.subjectSelenoproteinen_US
dc.subjectMethionine sulfoxideen_US
dc.subjectOxidative stressen_US
dc.subjectAntioxidantsen_US
dc.subjectPosttranslational modificationen_US
dc.titleSelenium and the Methionine Sulfoxide Reductase Systemen_US
dc.typeArticleen_US
kusw.kuauthorOien, Derek B.
kusw.kuauthorMoskovitz, Jackob
kusw.kudepartmentPharmacology and Toxicologyen_US
dc.identifier.doi10.3390/molecules14072337en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6254969en_US
dc.rights.accessrightsopenAccessen_US


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© 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.
Except where otherwise noted, this item's license is described as: © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.