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dc.contributor.authorNayar, Kritika
dc.contributor.authorMcKinney, Walker
dc.contributor.authorHogan, Abigail L.
dc.contributor.authorMartin, Gary E.
dc.contributor.authorLa Valle, Chelsea
dc.contributor.authorSharp, Kevin
dc.contributor.authorBerry-Kravis, Elizabeth
dc.contributor.authorNorton, Elizabeth S.
dc.contributor.authorGordon, Peter C.
dc.contributor.authorLosh, Molly
dc.date.accessioned2020-11-17T21:52:26Z
dc.date.available2020-11-17T21:52:26Z
dc.date.issued2019-07-26
dc.identifier.citationNayar, K., McKinney, W., Hogan, A. L., Martin, G. E., La Valle, C., Sharp, K., Berry-Kravis, E., Norton, E. S., Gordon, P. C., & Losh, M. (2019). Language processing skills linked to FMR1 variation: A study of gaze-language coordination during rapid automatized naming among women with the FMR1 premutation. PloS one, 14(7), e0219924. https://doi.org/10.1371/journal.pone.0219924en_US
dc.identifier.urihttp://hdl.handle.net/1808/30866
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractThe FMR1 premutation (PM) is relatively common in the general population. Evidence suggests that PM carriers may exhibit subtle differences in specific cognitive and language abilities. This study examined potential mechanisms underlying such differences through the study of gaze and language coordination during a language processing task (rapid automatized naming; RAN) among female carriers of the FMR1 PM. RAN taps a complex set of underlying neuropsychological mechanisms, with breakdowns implicating processing disruptions in fundamental skills that support higher order language and executive functions, making RAN (and analysis of gaze/language coordination during RAN) a potentially powerful paradigm for revealing the phenotypic expression of the FMR1 PM. Forty-eight PM carriers and 56 controls completed RAN on an eye tracker, where they serially named arrays of numbers, letters, colors, and objects. Findings revealed a pattern of inefficient language processing in the PM group, including a greater number of eye fixations (namely, visual regressions) and reduced eye-voice span (i.e., the eyes’ lead over the voice) relative to controls. Differences were driven by performance in the latter half of the RAN arrays, when working memory and processing load are the greatest, implicating executive skills. RAN deficits were associated with broader social-communicative difficulties among PM carriers, and with FMR1-related molecular genetic variation (higher CGG repeat length, lower activation ratio, and increased levels of the fragile X mental retardation protein; FMRP). Findings contribute to an understanding of the neurocognitive profile of PM carriers and indicate specific gene-behavior associations that implicate the role of the FMR1 gene in language-related processes.en_US
dc.description.sponsorshipNIH R01DC010191en_US
dc.description.sponsorshipNIH R01MH091131en_US
dc.description.sponsorshipNIH P30 HD03110en_US
dc.publisherPublic Library of Scienceen_US
dc.rights© 2019 Nayar et al.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleLanguage processing skills linked to FMR1 variation: A study of gaze-language coordination during rapid automatized naming among women with the FMR1 premutationen_US
dc.typeArticleen_US
kusw.kuauthorMcKinney, Walker
kusw.kudepartmentClinical Child Psychology Programen_US
dc.identifier.doi10.1371/journal.pone.0219924en_US
dc.identifier.orcidhttps://orcid.org/0000-0002-9823-8249en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6660192en_US
dc.rights.accessrightsopenAccessen_US


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© 2019 Nayar et al.
Except where otherwise noted, this item's license is described as: © 2019 Nayar et al.