Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: A case report
dc.contributor.author | Kaufman, Carolyn S. | |
dc.contributor.author | Bai, Stephen X. | |
dc.contributor.author | Ward, Jaimie L. | |
dc.contributor.author | Eickmeyer, Sarah M. | |
dc.contributor.author | Billinger, Sandra A. | |
dc.date.accessioned | 2020-09-21T13:51:22Z | |
dc.date.available | 2020-09-21T13:51:22Z | |
dc.date.issued | 2019-11-05 | |
dc.identifier.uri | http://hdl.handle.net/1808/30752 | |
dc.description | A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml. | en_US |
dc.description.abstract | Blood flow regulation is impaired in people with stroke. However, the time course of change in middle cerebral artery velocity (MCAv) following repeated stroke at rest and during exercise remains unknown. In this case study, we provide novel characterization of the dynamic kinetic MCAv response profile to moderate‐intensity exercise before and after repeated ischemic MCA stroke. The initial stroke occurred in the left MCA. At 3 months poststroke, left MCAv amplitude (Amp) was ~50% lower than the right. At the 6‐month follow‐up visit, MCAv Amp declined in both MCA with the left MCAv Amp ~50% lower than the right MCAv Amp. Following a second right MCA stroke, we report further decline in Amp for the left MCA. At the 3‐ and 6‐month visit following the second stroke, the left MCAv Amp declined further (~10%). The right MCAv Amp dramatically decreased by 81.3% when compared to the initial study visit. The MCAv kinetic analysis revealed a marked impairment in the cerebrovascular response to exercise following stroke. We discuss potential pathophysiological mechanisms contributing to poststroke cerebrovascular dysfunction and the need to test therapeutic interventions (such as exercise) that might attenuate cerebrovascular decline in people following stroke. | en_US |
dc.description.sponsorship | Eunice Kennedy Shriver National Institute of Child Health and Human Development (K01HD067318) | en_US |
dc.description.sponsorship | CTSA grant from NCATS awarded to the University of Kansas for Frontiers: University of Kansas Clinical and Translational Science Institute (# UL1TR002366) | en_US |
dc.description.sponsorship | CTSA Award # UL1TR000001 from NCRR and NCATS | en_US |
dc.description.sponsorship | Georgia Holland Endowment Fund | en_US |
dc.publisher | Physiological Society | en_US |
dc.rights | Copyright 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This work is licensed under a Creative Commons Attribution 4.0 International License. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Cerebrovascular | en_US |
dc.subject | Exercise | en_US |
dc.subject | Stroke, | en_US |
dc.subject | Ultrasound | en_US |
dc.title | Middle cerebral artery velocity dynamic response profile during exercise is attenuated following multiple ischemic strokes: A case report | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Kaufman, Carolyn S. | |
kusw.kuauthor | Bai, Stephen X. | |
kusw.kuauthor | Ward, Jaimie L. | |
kusw.kuauthor | Eickmeyer, Sarah M. | |
kusw.kuauthor | Billinger, Sandra A. | |
kusw.kudepartment | Molecular and Integrative Physiology | en_US |
kusw.kudepartment | Therapy and Rehabilitation Science | en_US |
kusw.kudepartment | Medicine and Rehabilitation | en_US |
kusw.kudepartment | Neurology | en_US |
dc.identifier.doi | 10.14814/phy2.14268 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-1618-7207 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: Copyright 2019 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of
The Physiological Society and the American Physiological Society. This work is licensed under a Creative Commons Attribution 4.0 International License.