Novel Traits, Flower Symmetry, and Transcriptional Autoregulation: New Hypotheses From Bioinformatic and Experimental Data

View/ Open
Issue Date
2018-10-26Author
Sengupta, Aniket
Hileman, Lena C.
Publisher
Frontiers Media
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
© 2018 Sengupta and Hileman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Metadata
Show full item recordAbstract
A common feature in developmental networks is the autoregulation of transcription
factors which, in turn, positively or negatively regulate additional genes critical for
developmental patterning. When a transcription factor regulates its own expression
by binding to cis-regulatory sites in its gene, the regulation is direct transcriptional
autoregulation (DTA). Indirect transcriptional autoregulation (ITA) involves regulation
by proteins expressed downstream of the target transcription factor. We review
evidence for a hypothesized role of DTA in the evolution and development of novel
flowering plant phenotypes. We additionally provide new bioinformatic and experimental
analyses that support a role for transcriptional autoregulation in the evolution of flower
symmetry. We find that 50 upstream non-coding regions are significantly enriched for
predicted autoregulatory sites in Lamiales CYCLOIDEA genes—an upstream regulator
of flower monosymmetry. This suggests a possible correlation between autoregulation
of CYCLOIDEA and the origin of monosymmetric flowers near the base of Lamiales,
a pattern that may be correlated with independently derived monosymmetry across
eudicot lineages. We find additional evidence for transcriptional autoregulation in the
flower symmetry program, and report that Antirrhinum DRIF2 may undergo ITA. In
light of existing data and new data presented here, we hypothesize how cis-acting
autoregulatory sites originate, and find evidence that such sites (and DTA) can arise
subsequent to the evolution of a novel phenotype.
Description
A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.
Collections
Citation
Sengupta A and Hileman LC (2018)
Novel Traits, Flower Symmetry,
and Transcriptional Autoregulation:
New Hypotheses From Bioinformatic
and Experimental Data.
Front. Plant Sci. 9:1561.
doi: 10.3389/fpls.2018.01561
Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.