Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain
dc.contributor.author | Yang, Fu-Chen | |
dc.contributor.author | Draper, Julia | |
dc.contributor.author | Smith, Peter G. | |
dc.contributor.author | Vivian, Jay L. | |
dc.contributor.author | Shapiro, Steven M. | |
dc.contributor.author | Stanford, John A. | |
dc.date.accessioned | 2019-08-30T14:48:09Z | |
dc.date.available | 2019-08-30T14:48:09Z | |
dc.date.issued | 2018-05-30 | |
dc.identifier.citation | Yang, F.-C., Draper, J., Smith, P. G., Vivian, J. L., Shapiro, S. M., & Stanford, J. A. (2018). Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain. Cell Transplantation, 27(4), 654–665. https://doi.org/10.1177/0963689718766327 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/29452 | |
dc.description | A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml. | en_US |
dc.description.abstract | Neonatal hyperbilirubinemia targets specific brain regions and can lead to kernicterus. One of the most debilitating symptoms of kernicterus is dystonia, which results from bilirubin toxicity to the globus pallidus (GP). Stem cell transplantation into the GP to replace lost neurons and restore basal ganglia circuits function is a potential therapeutic strategy to treat dystonia in kernicterus. In this study we transplanted human medial ganglionic eminence (MGE)-like neural progenitor cells (NPCs) that we differentiated into a primarily gamma-aminobutyric acid (GABA)ergic phenotype, into the GP of non-immunosuppressed jaundiced (jj) and non-jaundiced (Nj) rats. We assessed the survival and development of graft cells at three time-points post-transplantation. While grafted MGE-like NPCs survived and generated abundant fibers in both jj and Nj brains, NPC survival was greater in the jj brain. These results were consistent with our previous finding that excitatory spinal interneuron-like NPCs exhibited a higher survival rate in the jj brain than in the Nj brain. Our findings further support our hypothesis that slightly elevated bilirubin levels in the jj brain served as an antioxidant and immunosuppressant to protect the transplanted cells. We also identified graft fibers growing toward brain regions that receive projections from the GP, as well as host fibers extending toward the graft. These promising findings suggest that MGE-like NPCs may have the capacity to restore the circuits connecting GP and other nuclei. | en_US |
dc.description.sponsorship | NIH Center of Biomedical Research Excellence program project P20 GM104936 | en_US |
dc.description.sponsorship | Children's Mercy Hospital | en_US |
dc.description.sponsorship | Ronald D. Deffenbaugh Foundation | en_US |
dc.description.sponsorship | Kansas Intellectual and Developmental Disabilities Research Center HD090216 | en_US |
dc.publisher | SAGE Publications | en_US |
dc.rights | Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). | en_US |
dc.rights.uri | http://www.creativecommons.org/licenses/by-nc/4.0/ | en_US |
dc.subject | Bilirubin Encephalopathy | en_US |
dc.subject | globus pallidus | en_US |
dc.subject | Gunn rat | en_US |
dc.subject | xenotransplantation | en_US |
dc.subject | MGE-like NPC | en_US |
dc.title | Short Term Development and Fate of MGE-Like Neural Progenitor Cells in Jaundiced and Non-Jaundiced Rat Brain | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Stanford, John A. | |
kusw.kudepartment | Molecular and Integrative Phsiology | en_US |
dc.identifier.doi | 10.1177/0963689718766327 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0
License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further
permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).