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    Exploring the Gut Microbiome in Chronic Kidney Disease

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    Available after: 2020-05-31 (13.82Mb)
    Issue Date
    2018-05-31
    Author
    Johnson, Cassi
    Publisher
    University of Kansas
    Format
    106 pages
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Anatomy & Cell Biology
    Rights
    Copyright held by the author.
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    Abstract
    Patients with chronic kidney disease (CKD) exhibit a disproportionate burden of cardiovascular disease and other comorbid conditions compared to the general population. It is speculated that this increased burden of comorbid conditions is partially driven by the systemic accumulation of gut-derived bacterial byproducts and the ensuing activation of innate immune pathways. As a result, researchers have directed their attention to the intestinal microbiome as a novel therapeutic target for reducing morbidity and mortality in CKD patients. In this dissertation, I will first summarize the current state of knowledge regarding the complex interactions between the intestinal microbiota and gut barrier function, highlighting how intestinal bacteria and components of the intestinal barrier contribute to the maintenance of an immune tolerant environment. Next, I will review the existing literature regarding the contribution of intestinal dysbiosis to chronic disease states, including CKD. Lastly, I will review the findings from my own experiments focused on: (1) determining how CKD alters the metabolism of trimethylamine N-oxide (TMAO), a novel uremic toxin that correlates with cardiovascular risk in CKD, and (2) characterizing how CKD impacts the expression patterns and activity of intestinal and hepatic alkaline phosphatases, a group of enzymes involved in the detoxification bacterial endotoxins and maintenance of intestinal barrier function.
    URI
    http://hdl.handle.net/1808/29302
    Collections
    • KU Med Center Dissertations and Theses [464]
    • Dissertations [4473]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
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    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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