KUKU

KU ScholarWorks

  • myKU
  • Email
  • Enroll & Pay
  • KU Directory
    • Login
    View Item 
    •   KU ScholarWorks
    • Dissertations and Theses
    • Theses
    • View Item
    •   KU ScholarWorks
    • Dissertations and Theses
    • Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    An Acute Bout of Concurrent Exercise on Mechanotransducing Properties of the Skeletal Muscle Fiber

    Thumbnail
    View/Open
    Olsen_ku_0099M_16200_DATA_1.pdf (643.3Kb)
    Issue Date
    2018-12-31
    Author
    Olsen, Luke
    Publisher
    University of Kansas
    Format
    65 pages
    Type
    Thesis
    Degree Level
    M.S.
    Discipline
    Health, Sport and Exercise Sciences
    Rights
    Copyright held by the author.
    Metadata
    Show full item record
    Abstract
    Aim: It was the aim of this study to extrapolate the affect which an acute bout of concurrent training, aerobic exercise coupled with resistance exercise, as compared to resistance exercise alone, has on the mechanically sensitive signaling proteins of the muscle fiber and their downstream signaling proteins as to give insight into the intracellular metabolic milieu. Methods: Eleven healthy males performed unilateral tricep extension exercise with both arms. One randomly designated arm took part in the concurrent training bout comprising an acute aerobic intervention shortly followed by resistance exercise. Biopsies were obtained from the M. Triceps Brachii at three time-points; Pre-RE, Post+15 RE, and post+3-hr RE. Tissue was then analyzed for mechanically sensitive proteins A7B1 Integrin, Yes-Associated Protein, Focal Adhesion Kinase, and downstream signaling proteins AMP-Kinase, p70s6k, and 4ebp1. Results: AMPK showed a significant carm X time interaction (p < 0.05). P70s6k showed no condition X time interaction. 4E-BP-1 showed a significant condition X time interaction (p< 0.05). Beta-1 Integrin showed a main effect of time increasing from time-point 1 to time-point 3 across both arms. FAK showed a main effect of time decreasing from time-point 1 to time-point 3 across both arms. YAP showed no condition X time interaction. Conclusions: Here we demonstrate the ability of the triceps brachaii to respond in a similar manner between concurrent exercise and resistance-only exercise concerning the skeletal muscle specific integrin isoform, alpha7 beta1. Moreover, we demonstrate the large decrease of 4E-BP1 and increase of AMPK immediately following the AE protocol along with possible augmentation of FAK through AMPK inhibitory mechanisms. This denotes the possibility that, as compared to past studies, the triceps brachaii uniquely responds and regulates intracellular remodeling mechanisms following an acute bout of concurrent exercise as compared to the lower body.
    URI
    http://hdl.handle.net/1808/28020
    Collections
    • Education Dissertations and Theses [1065]
    • Theses [3768]

    Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.


    We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.


    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    Browse

    All of KU ScholarWorksCommunities & CollectionsThis Collection

    My Account

    Login

    Statistics

    View Usage Statistics

    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    The University of Kansas
      Contact KU ScholarWorks
    Lawrence, KS | Maps
     
    • Academics
    • Admission
    • Alumni
    • Athletics
    • Campuses
    • Giving
    • Jobs

    The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University’s programs and activities. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA@ku.edu, 1246 W. Campus Road, Room 153A, Lawrence, KS, 66045, (785)864-6414, 711 TTY.

     Contact KU
    Lawrence, KS | Maps