High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation
dc.contributor.author | Hu, Zizhong | |
dc.contributor.author | Zhang, Haonan | |
dc.contributor.author | Mordovanakis, Aghapi | |
dc.contributor.author | Paulus, Yannis M. | |
dc.contributor.author | Liu, Qinghuai | |
dc.contributor.author | Wang, Xueding | |
dc.contributor.author | Yang, Xinmai | |
dc.date.accessioned | 2018-11-19T20:33:04Z | |
dc.date.available | 2018-11-19T20:33:04Z | |
dc.date.issued | 2017-01-11 | |
dc.identifier.citation | Hu, Z. et al. High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation. Sci. Rep. 7, 40243; doi: 10.1038/srep40243 (2017). | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/27401 | |
dc.description.abstract | Antivascular therapy represents a proven strategy to treat angiogenesis. By applying synchronized ultrasound bursts and nanosecond laser irradiation, we developed a novel, selective, non-invasive, localized antivascular method, termed photo-mediated ultrasound therapy (PUT). PUT takes advantage of the high native optical contrast among biological tissues and can treat microvessels without causing collateral damage to the surrounding tissue. In a chicken yolk sac membrane model, under the same ultrasound parameters (1 MHz at 0.45 MPa and 10 Hz with 10% duty cycle), PUT with 4 mJ/cm2 and 6 mJ/cm2 laser fluence induced 51% (p = 0.001) and 37% (p = 0.018) vessel diameter reductions respectively. With 8 mJ/cm2 laser fluence, PUT would yield vessel disruption (90%, p < 0.01). Selectivity of PUT was demonstrated by utilizing laser wavelengths at 578 nm or 650 nm, where PUT selectively shrank veins or occluded arteries. In a rabbit ear model, PUT induced a 68.5% reduction in blood perfusion after 7 days (p < 0.001) without damaging the surrounding cells. In vitro experiments in human blood suggested that cavitation may play a role in PUT. In conclusion, PUT holds significant promise as a novel non-invasive antivascular method with the capability to precisely target blood vessels. | en_US |
dc.description.sponsorship | R01AR060350 | en_US |
dc.description.sponsorship | R01CA186769 | en_US |
dc.description.sponsorship | 4K12EY022299-4 | en_US |
dc.description.sponsorship | BL2014089) | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Biomedical engineering | en_US |
dc.subject | Radiotherapy | en_US |
dc.subject | Surgical oncology | en_US |
dc.subject | Translational research | en_US |
dc.title | High-precision, non-invasive anti-microvascular approach via concurrent ultrasound and laser irradiation | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Yang, Xinmai | |
kusw.kudepartment | Mechanical Engineering | en_US |
dc.identifier.doi | 10.1038/srep40243 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.