Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus
dc.contributor.author | de Vries, Ronald | |
dc.contributor.author | Riley, Robert | |
dc.contributor.author | Wiebenga, Ad | |
dc.contributor.author | Aguilar-Osorio, Guillermo | |
dc.contributor.author | Amillis, Sotiris | |
dc.contributor.author | Uchima, Cristiane Akemi | |
dc.contributor.author | Anderluh, Gregor | |
dc.contributor.author | Asadollahi, Mojtaba | |
dc.contributor.author | Askin, Marion | |
dc.contributor.author | Barry, Kerrie | |
dc.contributor.author | Battaglia, Evy | |
dc.contributor.author | Bayram, Özgür | |
dc.contributor.author | Benocci, Tiziano | |
dc.contributor.author | Braus-Stromeyer, Susanna A. | |
dc.contributor.author | Caldana, Camila | |
dc.date.accessioned | 2018-11-14T19:48:31Z | |
dc.date.available | 2018-11-14T19:48:31Z | |
dc.date.issued | 2017-02-14 | |
dc.identifier.citation | de Vries, R. P., Riley, R., Wiebenga, A., Aguilar-Osorio, G., Amillis, S., Uchima, C. A., ... & Battaglia, E. (2017). Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome biology, 18(1), 28. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/27351 | |
dc.description.abstract | Background The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus.Results We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli.Conclusions Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi. | en_US |
dc.publisher | BMC | en_US |
dc.rights | © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Aspergillus | en_US |
dc.subject | Genome sequencing | en_US |
dc.subject | Comparative genomics | en_US |
dc.subject | Fungal biology | en_US |
dc.title | Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Oakley, Berl Ray | |
kusw.kudepartment | Molecular Biosciences | en_US |
kusw.oanotes | Per SHERPA/RoMEO 11/14/18: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: green tick author can archive publisher's version/PDF General Conditions: Author's pre-print on pre-print server such as ArXiv, bioRxiv, Peer J PrePrints, or similar platforms (both commercial and non-commercial) Authors post-print and Publisher's version/PDF on any website Publisher's version/PDF may be used Creative Commons Attribution License Copy of License must accompany any deposit. Authors retain copyright Published source must be acknowledged Must link to publisher version with DOI | en_US |
dc.identifier.doi | 10.1186/s13059-017-1151-0 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
kusw.proid | 142425049088 | en_US |
dc.rights.accessrights | openAccess | en_US |
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