A resting EEG study of neocortical hyperexcitability and altered functional connectivity in fragile X syndrome
dc.contributor.author | Wang, Jun | |
dc.contributor.author | Ethridge, Lauren E. | |
dc.contributor.author | Mosconi, Matthew W. | |
dc.contributor.author | White, Stormi P. | |
dc.contributor.author | Binder, Devin K. | |
dc.contributor.author | Pedapati, Ernest V. | |
dc.contributor.author | Erickson, Craig A. | |
dc.contributor.author | Byerly, Matthew J. | |
dc.contributor.author | Sweeney, John A. | |
dc.date.accessioned | 2018-11-13T19:06:00Z | |
dc.date.available | 2018-11-13T19:06:00Z | |
dc.date.issued | 2017-03-14 | |
dc.identifier.citation | Wang, J., Ethridge, L. E., Mosconi, M. W., White, S. P., Binder, D. K., Pedapati, E. V., ... & Sweeney, J. A. (2017). A resting EEG study of neocortical hyperexcitability and altered functional connectivity in fragile X syndrome. Journal of neurodevelopmental disorders, 9(1), 11 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/27315 | |
dc.description.abstract | Background Cortical hyperexcitability due to abnormal fast-spiking inhibitory interneuron function has been documented in fmr1 KO mice, a mouse model of the fragile X syndrome which is the most common single gene cause of autism and intellectual disability.Methods We collected resting state dense-array electroencephalography data from 21 fragile X syndrome (FXS) patients and 21 age-matched healthy participants.Results FXS patients exhibited greater gamma frequency band power, which was correlated with social and sensory processing difficulties. Second, FXS patients showed increased spatial spreading of phase-synchronized high frequency neural activity in the gamma band. Third, we observed increased negative theta-to-gamma but decreased alpha-to-gamma band amplitude coupling, and the level of increased theta power was inversely related to the level of resting gamma power in FXS.Conclusions Increased theta band power and coupling from frontal sources may represent a mechanism providing compensatory inhibition of high-frequency gamma band activity, potentially contributing to the widely varying level of neurophysiological and behavioral abnormalities and treatment response seen in full-mutation FXS patients. These findings extend preclinical observations and provide new mechanistic insights into brain alterations and their variability across FXS patients. Electrophysiological measures may provide useful translational biomarkers for advancing drug development and individualizing treatments for neurodevelopmental disorders with associated neuronal hyperexcitability. | en_US |
dc.publisher | BMC | en_US |
dc.rights | © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Fragile X syndrome | en_US |
dc.subject | EEG | en_US |
dc.subject | Hyperexcitability | en_US |
dc.subject | Gamma | en_US |
dc.subject | Cross-frequency coupling | en_US |
dc.subject | Top-down modulation | en_US |
dc.title | A resting EEG study of neocortical hyperexcitability and altered functional connectivity in fragile X syndrome | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Mosconi, Matthew W. | |
kusw.kudepartment | Applied Behavioral Science | en_US |
kusw.oanotes | Per SHERPA/RoMEO 11/13/18: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: green tick author can archive publisher's version/PDF General Conditions: Author's pre-print on pre-print server such as ArXiv, bioRxiv, Peer J PrePrints, or similar platforms (both commercial and non-commercial) Authors post-print and Publisher's version/PDF on any website Publisher's version/PDF may be used Creative Commons Attribution License Copy of License must accompany any deposit. Authors retain copyright Published source must be acknowledged Must link to publisher version with DOI | en_US |
dc.identifier.doi | 10.1186/s11689-017-9191-z | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
kusw.proid | 151674564608 | en_US |
dc.rights.accessrights | openAccess | en_US |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: © The Author(s). 2017
Open Access
This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated