Crosstalk and the evolvability of intracellular communication
dc.contributor.author | Rowland, Michael A. | |
dc.contributor.author | Greenbaum, Joseph M. | |
dc.contributor.author | Deeds, Eric J. | |
dc.date.accessioned | 2018-11-01T16:46:40Z | |
dc.date.available | 2018-11-01T16:46:40Z | |
dc.date.issued | 2017-07-10 | |
dc.identifier.citation | Rowland, M. A., Greenbaum, J. M., Deeds, E. J., (2017), Crosstalk and the evolvability of intracellular communication, Nature Research, https://doi.org/10.1038/ncomms16009 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/27125 | |
dc.description.abstract | Metazoan signalling networks are complex, with extensive crosstalk between pathways. It is unclear what pressures drove the evolution of this architecture. We explore the hypothesis that crosstalk allows different cell types, each expressing a specific subset of signalling proteins, to activate different outputs when faced with the same inputs, responding differently to the same environment. We find that the pressure to generate diversity leads to the evolution of networks with extensive crosstalk. Using available data, we find that human tissues exhibit higher levels of diversity between cell types than networks with random expression patterns or networks with no crosstalk. We also find that crosstalk and differential expression can influence drug activity: no protein has the same impact on two tissues when inhibited. In addition to providing a possible explanation for the evolution of crosstalk, our work indicates that consideration of cellular context will likely be crucial for targeting signalling networks. | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.title | Crosstalk and the evolvability of intracellular communication | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Deeds, Eric J. | |
kusw.kudepartment | Computational Biology | en_US |
dc.identifier.doi | https://doi.org/10.1038/ncomms16009 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.