dc.contributor.advisor | Carlson, Susan E | |
dc.contributor.author | Littrell, Juleah | |
dc.date.accessioned | 2018-10-26T20:27:59Z | |
dc.date.available | 2018-10-26T20:27:59Z | |
dc.date.issued | 2018-05-31 | |
dc.date.submitted | 2018 | |
dc.identifier.other | http://dissertations.umi.com/ku:15906 | |
dc.identifier.uri | http://hdl.handle.net/1808/27084 | |
dc.description.abstract | Background: Long chain polyunsaturated fatty acids (LCPUFAs) have been shown to reduce blood pressure (BP) while they are being consumed; however, there is also evidence from observational studies that exposure to more LCPUFA early in development can program lower BP in childhood. This relationship has yet to be studied in a randomized trial conducted during fetal life. Objective: We tested the hypothesis that 600 mg/d of the omega-3 LCPUFA docosahexaenoic acid (DHA) compared to placebo in pregnancy can reduce offspring BP at 7 and 8 years of age. Methods: This secondary data analysis examines 129 offspring from women who consumed capsules (placebo or 600 mg DHA) from <20 weeks of gestation to birth. BP was measured in triplicate at 7 and 8 years of age. The statistical analysis was intent-to-treat with adjustment for covariates associated with BP. Results: We did not find an effect of early DHA exposure on BP, however, child weight status (BMI percentile < or ≥85th percentile) and gestational days smoked were positively associated with BP at 7 and 8 years of age. Conclusion: Improving maternal and therefore fetal DHA status through maternal DHA supplementation during pregnancy does not appear to protect against higher BP at 7 and 8 years of age. | |
dc.format.extent | 41 pages | |
dc.language.iso | en | |
dc.publisher | University of Kansas | |
dc.rights | Copyright held by the author. | |
dc.subject | Nutrition | |
dc.subject | blood pressure | |
dc.subject | childhood | |
dc.subject | DHA | |
dc.subject | docosahexaenoic acid | |
dc.subject | pregnancy | |
dc.title | Docosahexaenoic Acid and Childhood Blood Pressure | |
dc.type | Thesis | |
dc.contributor.cmtemember | Kerling, Elizabeth H | |
dc.contributor.cmtemember | Hull, Holly R | |
dc.thesis.degreeDiscipline | Dietetics & Nutrition | |
dc.thesis.degreeLevel | M.S. | |
dc.identifier.orcid | | |
dc.rights.accessrights | openAccess | |