Optimal control and cost-effective analysis of malaria/visceral leishmaniasis co-infection
| dc.contributor.author | Agusto, Folashade B. | |
| dc.contributor.author | ELmojtaba, Ibrahim M. | |
| dc.date.accessioned | 2018-09-28T16:51:19Z | |
| dc.date.available | 2018-09-28T16:51:19Z | |
| dc.date.issued | 2017 | |
| dc.identifier.citation | Agusto FB, ELmojtaba IM (2017) Optimal control and cost-effective analysis of malaria/visceral leishmaniasis co-infection. PLoS ONE 12(2): e0171102. doi:10.1371/journal.pone.0171102 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/26769 | |
| dc.description.abstract | In this paper, a deterministic model involving the transmission dynamics of malaria/visceral leishmaniasis co-infection is presented and studied. Optimal control theory is then applied to investigate the optimal strategies for curtailing the spread of the diseases using the use of personal protection, indoor residual spraying and culling of infected reservoirs as the system control variables. Various combination strategies were examined so as to investigate the impact of the controls on the spread of the disease. And we investigated the most cost-effective strategy of all the control strategies using three approaches, the infection averted ratio (IAR), the average cost-effectiveness ratio (ACER) and incremental cost-effectiveness ratio (ICER). Our results show that the implementation of the strategy combining all the time dependent control variables is the most cost-effective control strategy. This result is further emphasized by using the results obtained from the cost objective functional, the ACER, and the ICER | en_US |
| dc.publisher | Public Library of Science | en_US |
| dc.rights | © 2017 Agusto, ELmojtaba. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.title | Optimal control and cost-effective analysis of malaria/visceral leishmaniasis co-infection | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Agusto, Folashade, B. | |
| kusw.kudepartment | Ecology & Evolutionary Biology | en_US |
| dc.identifier.doi | 10.1371/journal.pone.0171102 | en_US |
| kusw.oaversion | Scholarly/refereed, publisher version | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: © 2017 Agusto, ELmojtaba. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
