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    Connecting QTLS to the G-Matrix of Evolutionary Quantitative Genetics

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    Kelly_2009.pdf (1.188Mb)
    Issue Date
    2009-04
    Author
    Kelly, John K.
    Publisher
    Wiley
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
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    Abstract
    Evolutionary quantitative genetics has recently advanced in two distinct streams. Many biologists address evolutionary questions by estimating phenotypic selection and genetic (co)variances (G matrices). Simultaneously, an increasing number of studies have applied quantitative trait locus (QTL) mapping methods to dissect variation. Both conceptual and practical difficulties have isolated these two foci of quantitative genetics. A conceptual integration follows from the recognition that QTL allele frequencies are the essential variables relating the G-matrix to marker-based mapping experiments. Breeding designs initiated from randomly selected parental genotypes can be used to estimate QTL-specific genetic (co)variances. These statistics appropriately distill allelic variation and provide an explicit population context for QTL mapping estimates. Within this framework, one can parse the G-matrix into a set of mutually exclusive genomic components and ask whether these parts are similar or dissimilar in their respective features, for example the magnitude of phenotypic effects and the extent and nature of pleiotropy. As these features are critical determinants of sustained response to selection, the integration of QTL mapping methods into G-matrix estimation can provide a concrete, genetically based experimental program to investigate the evolutionary potential of natural populations.
    Description
    This is the peer reviewed version of the following article: Kelly, J. K. (2009), CONNECTING QTLS TO THE G‐MATRIX OF EVOLUTIONARY QUANTITATIVE GENETICS. Evolution, 63: 813-825. doi:10.1111/j.1558-5646.2008.00590.x, which has been published in final form at http://doi.org/10.1111/j.1558-5646.2008.00590.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
    URI
    http://hdl.handle.net/1808/26457
    DOI
    https://doi.org/10.1111/j.1558-5646.2008.00590.x
    Collections
    • Ecology & Evolutionary Biology Scholarly Works [1497]
    Citation
    Kelly, J. K. (2009). CONNECTING QTLS TO THE G-MATRIX OF EVOLUTIONARY QUANTITATIVE GENETICS. Evolution; International Journal of Organic Evolution, 63(4), 813–825. http://doi.org/10.1111/j.1558-5646.2008.00590.x

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    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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