Show simple item record

dc.contributor.authorCrawford, Michael H.
dc.contributor.authorFagundes, Nelson J. R.
dc.contributor.authorTagliani-Ribeiro, Alice
dc.contributor.authorRubicz, Rohina
dc.contributor.authorTarskaia, Larissa
dc.contributor.authorSalzano, Francisco M.
dc.contributor.authorBonatto, Sandro L.
dc.date.accessioned2018-06-05T16:21:21Z
dc.date.available2018-06-05T16:21:21Z
dc.date.issued2018-01-01
dc.identifier.citationFagundes, Nelson J.R., Tagliani-Ribeiro, Alice, Rubicz, Rohina, Tarskaia, Larissa, Crawford, Michael H., Salzano, Francisco M., & Bonatto, Sandro L.. (2018). How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data. Genetics and Molecular Biology, 41(1, Suppl. 1), 206-214. https://dx.doi.org/10.1590/1678-4685-gmb-2017-0087en_US
dc.identifier.urihttp://hdl.handle.net/1808/26453
dc.description.abstractIn spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus has emerged about important parameters such as the effective size of the Native Americans founder population. Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important for determining the extent of genetic markers needed to characterize Native American populations in genome-wide studies and to evaluate the adaptive potential of genetic variants in this population.en_US
dc.publisherSociedade Brasileira de Genéticaen_US
dc.rightsLicense information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.enen_US
dc.subjectIsolation with Migration modelen_US
dc.subjectCoalescent analysisen_US
dc.subjectNative Siberiansen_US
dc.titleHow strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence dataen_US
dc.typeArticleen_US
kusw.kuauthorCrawford, Michael
kusw.kudepartmentAnthropologyen_US
dc.identifier.doi10.1590/1678-4685-gmb-2017-0087 en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.rights.accessrightsopenAccessen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

License information: This is an open-access article distributed under the terms of the
Creative Commons Attribution License (type CC-BY), which permits unrestricted use,
distribution and reproduction in any medium, provided the original article is properly cited.
Except where otherwise noted, this item's license is described as: License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.