How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data
dc.contributor.author | Crawford, Michael H. | |
dc.contributor.author | Fagundes, Nelson J. R. | |
dc.contributor.author | Tagliani-Ribeiro, Alice | |
dc.contributor.author | Rubicz, Rohina | |
dc.contributor.author | Tarskaia, Larissa | |
dc.contributor.author | Salzano, Francisco M. | |
dc.contributor.author | Bonatto, Sandro L. | |
dc.date.accessioned | 2018-06-05T16:21:21Z | |
dc.date.available | 2018-06-05T16:21:21Z | |
dc.date.issued | 2018-01-01 | |
dc.identifier.citation | Fagundes, Nelson J.R., Tagliani-Ribeiro, Alice, Rubicz, Rohina, Tarskaia, Larissa, Crawford, Michael H., Salzano, Francisco M., & Bonatto, Sandro L.. (2018). How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data. Genetics and Molecular Biology, 41(1, Suppl. 1), 206-214. https://dx.doi.org/10.1590/1678-4685-gmb-2017-0087 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/26453 | |
dc.description.abstract | In spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus has emerged about important parameters such as the effective size of the Native Americans founder population. Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important for determining the extent of genetic markers needed to characterize Native American populations in genome-wide studies and to evaluate the adaptive potential of genetic variants in this population. | en_US |
dc.publisher | Sociedade Brasileira de Genética | en_US |
dc.rights | License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited. | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/deed.en | en_US |
dc.subject | Isolation with Migration model | en_US |
dc.subject | Coalescent analysis | en_US |
dc.subject | Native Siberians | en_US |
dc.title | How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Crawford, Michael | |
kusw.kudepartment | Anthropology | en_US |
dc.identifier.doi | 10.1590/1678-4685-gmb-2017-0087 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: License information: This is an open-access article distributed under the terms of the
Creative Commons Attribution License (type CC-BY), which permits unrestricted use,
distribution and reproduction in any medium, provided the original article is properly cited.