Mitochondrial Perturbation in Alzheimer’s Disease and Diabetes
dc.contributor.author | Yan, Shirley ShiDu | |
dc.contributor.author | Yan, Shi Fang | |
dc.contributor.author | Chen, Doris | |
dc.contributor.author | Akhter, Firoz | |
dc.date.accessioned | 2018-05-21T18:44:33Z | |
dc.date.available | 2018-05-21T18:44:33Z | |
dc.date.issued | 2017-02-04 | |
dc.identifier.citation | Akhter, F., Chen, D., Yan, S. F., & Yan, S. S. (2017). Mitochondrial Perturbation in Alzheimer’s Disease and Diabetes. Progress in Molecular Biology and Translational Science, 146, 341–361. http://doi.org/10.1016/bs.pmbts.2016.12.019 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/26434 | |
dc.description.abstract | Mitochondria are well-known cellular organelles that play a vital role in cellular bioenergetics, heme biosynthesis, thermogenesis, calcium homeostasis, lipid catabolism, and other metabolic activities. Given the extensive role of mitochondria in cell function, mitochondrial dysfunction plays a part in many diseases, including diabetes and Alzheimer’s disease (AD). In most cases, there is overwhelming evidence that impaired mitochondrial function is a causative factor in these diseases. Studying mitochondrial function in diseased cells vs healthy cells may reveal the modified mechanisms and molecular components involved in specific disease states. In this chapter, we provide a concise overview of the major recent findings on mitochondrial abnormalities and their link to synaptic dysfunction relevant to neurodegeneration and cognitive decline in AD and diabetes. Our increased understanding of the role of mitochondrial perturbation indicates that the development of specific small molecules targeting aberrant mitochondrial function could provide therapeutic benefits for the brain in combating aging-related dementia and neurodegenerative diseases by powering up brain energy and improving synaptic function and transmission. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.title | Mitochondrial Perturbation in Alzheimer’s Disease and Diabetes | en_US |
dc.type | Article | en_US |
kusw.kudepartment | Higuchi Biosciences Center | en_US |
dc.identifier.doi | 10.1016/bs.pmbts.2016.12.019 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
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