| dc.contributor.author | Shannon, Stephen R. | |
| dc.contributor.author | Moise, Alexander R. | |
| dc.contributor.author | Trainor, Paul A. | |
| dc.date.accessioned | 2018-05-21T18:03:05Z | |
| dc.date.available | 2018-05-21T18:03:05Z | |
| dc.date.issued | 2017-05 | |
| dc.identifier.citation | Shannon, S. R., Moise, A. R., & Trainor, P. A. (2017). New insights and changing paradigms in the regulation of vitamin A metabolism in development. Wiley Interdisciplinary Reviews. Developmental Biology, 6(3), 10.1002/wdev.264. http://doi.org/10.1002/wdev.264 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/26433 | |
| dc.description | This is the peer reviewed version of the following article: Shannon, S. R., Moise, A. R., & Trainor, P. A. (2017). New insights and changing paradigms in the regulation of vitamin A metabolism in development. Wiley Interdisciplinary Reviews. Developmental Biology, 6(3), 10.1002/wdev.264, which has been published in final form at http://doi.org/10.1002/wdev.264 This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | |
| dc.description.abstract | Vitamin A and its active metabolite retinoic acid are essential for embryonic development and adult homeostasis. Surprisingly, excess or deficiency of vitamin A and retinoic acid can cause similar developmental defects. Therefore, strict feedback and other mechanisms exist to regulate the levels of retinoic acid within a narrow physiological range. The oxidation of vitamin A to retinal has recently been established as a critical nodal point in the synthesis of retinoic acid, and over the past decade, RDH10 and DHRS3 have emerged as the predominant enzymes that regulate this reversible reaction. Together they form a codependent complex that facilitates negative feedback maintenance of retinoic acid levels and thus guard against the effects of dysregulated vitamin A metabolism and retinoic acid synthesis. This review focuses on advances in our understanding of the roles of Rdh10 and Dhrs3 and their impact on development and disease. | en_US |
| dc.publisher | Wiley | en_US |
| dc.title | New insights and changing paradigms in the regulation of vitamin A metabolism in development | en_US |
| dc.type | Article | en_US |
| kusw.kudepartment | Pharmacy | en_US |
| kusw.oanotes | Per SHERPA/RoMEO 5/21/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing)
Author's Post-print: grey tick subject to Restrictions below, author can archive post-print (ie final draft post-refereeing)
Restrictions: 12 months embargoPublisher's Version/PDF: cross author cannot archive publisher's version/PDF
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On author's personal website, institutional repositories, arXiv, AgEcon, PhilPapers, PubMed Central, RePEc or Social Science Research Network
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Non-Commercial
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If OnlineOpen is available, BBSRC, EPSRC, MRC, NERC and STFC authors, may self-archive after 12 months | en_US |
| dc.identifier.doi | 10.1002/wdev.264 | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-2307-6035 | |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.rights.accessrights | openAccess | en_US |
