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dc.contributor.authorVarma, Vijay R.
dc.contributor.authorWatts, Amber
dc.identifier.citationVarma, V. R., & Watts, A. (2017). Daily physical activity patterns during the early stage of Alzheimer’s disease. Journal of Alzheimer’s Disease : JAD, 55(2), 659–667.
dc.description.abstractBackground - Alzheimer’s disease (AD) is a neurodegenerative disease that results in severe disability. Very few studies have explored changes in daily physical activity patterns during early stages of AD when components of physical function and mobility may be preserved. Methods - Patients with mild AD and controls (n=92) recruited from the University of Kansas Alzheimer’s Disease Center Registry, wore the Actigraph GT3X+ for seven days, and provided objective physical function (VO2 max) and mobility data. Using multivariate linear regression, we explored whether individuals with mild AD had different daily average and diurnal physical activity patterns compared to controls independent of non-cognitive factors that may affect physical activity, including physical function and mobility. Results - We found that mild AD was associated with less moderate-intensity physical activity (p<0.05), lower peak activity (p<0.01), and lower physical activity complexity (p<0.05) particularly during the morning. Mild AD was not associated with greater sedentary activity or less lower-intensity physical activity across the day after adjusting for non-cognitive covariates. Conclusions - These findings suggest that factors independent of physical capacity and mobility may drive declines in moderate-intensity physical activity, and not lower-intensity or sedentary activity, during the early stage of AD. This underscores the importance of a better mechanistic understanding of how cognitive decline and AD pathology impact physical activity. Findings emphasize the potential value of designing and testing time-of-day specific physical activity interventions targeting individuals in the early stages of AD, prior to significant declines in mobility and physical function.en_US
dc.publisherIOS Pressen_US
dc.rights© 2017 – IOS Press and the authors. All rights reserveden_US
dc.subjectPhysical fitnessen_US
dc.subjectAlzheimer diseaseen_US
dc.subjectMotor activityen_US
dc.subjectPhysical conditioningen_US
dc.subjectPhysical exertionen_US
dc.titleDaily physical activity patterns during the early stage of Alzheimer’s diseaseen_US
kusw.kuauthorWatts, Amber
kusw.oanotesPer SHERPA/RoMEO 4/26/2018: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions:

On author's personal website, institutional website or funder's website, including PubMed Central Non-commercial use only Publisher copyright and source must be acknowledged Author's version can be used Publisher's version/PDF cannot be used
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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