ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Association of QT interval with mortality by kidney function: results from the National Health and Nutrition Examination Survey (NHANES)
dc.contributor.author | Malik, Rehan | |
dc.contributor.author | Waheed, Sehrish | |
dc.contributor.author | Parashara, Deepak | |
dc.contributor.author | Perez, Jorge | |
dc.contributor.author | Waheed, Salman | |
dc.date.accessioned | 2018-02-21T16:47:44Z | |
dc.date.available | 2018-02-21T16:47:44Z | |
dc.date.issued | 2017-10-21 | |
dc.identifier.citation | Malik R, Waheed S, Parashara D, et al Association of QT interval with mortality by kidney function: results from the National Health and Nutrition Examination Survey (NHANES) Open Heart 2017;4:e000683. doi: 10.1136/openhrt-2017-000683 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/26052 | |
dc.description | A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml. | en_US |
dc.description.abstract | Objective Prolonged QT interval predisposes to ventricular arrhythmias and sudden cardiac death. However, the association between QT interval and mortality by the level of pre-existing kidney function has not been investigated.Methods We followed 6565 participants from the National Health and Nutrition Examination Survey III for a median of 13.3 years. Sample divided according to corrected QT (QTc) interval was as follows: normal (QTc <450 ms for men and <460 ms for women) or prolonged. It was further categorised as follows: (1) no chronic kidney disease (CKD), that is, albumin to creatinine ratio (ACR) <30 mg/g and estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m2 ⇓; (2) CKD by eGFR only (eGFR <60 mL/min/1.73 m2, ACR <30 mg/g); (3)⇓ CKD by ACR only (ACR >30 mg/g, eGFR >60 mL/min/1.73 m2) and ⇓(4) CKD by both. Cox proportional hazards models were used.Results CKD group had prolonged QTc than those without CKD (20.5%vs12.9%, p<0.0001). Both prolonged QTc and CKD are independently associated with increased risk of mortality. When combined, risk of mortality is higher in those with CKD by eGFR with prolonged QTc than normal QTc (HR 2.6 (1.7–3.9) and 3.1 (1.7–5.4) vs 1.4 (1.1–1.7) and 1.7 (1.3–2.1) for all-cause and CV mortality). There is no significant difference in risk in those with CKD by ACR when QTc is prolonged. There is significant improvement in risk prediction for all-cause and CV mortality when QTc is added to CKD beyond established CV risk factors (net reclassification index p<0.00001).Conclusion A screening ECG in those with CKD may help in finer risk stratification and may be considered | en_US |
dc.publisher | BMJ Publishing Group | en_US |
dc.rights | This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en_US |
dc.title | Association of QT interval with mortality by kidney function: results from the National Health and Nutrition Examination Survey (NHANES) | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1136/openhrt-2017-000683 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.