Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain
dc.contributor.author | Cooper, Michael A. | |
dc.contributor.author | Kluding, Patricia M. | |
dc.contributor.author | Wright, Douglas E. | |
dc.date.accessioned | 2017-09-01T19:20:38Z | |
dc.date.available | 2017-09-01T19:20:38Z | |
dc.date.issued | 2016-08 | |
dc.identifier.citation | Cooper, M. A., Kluding, P. M., & Wright, D. E. (2016). Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain. Frontiers in Neuroscience, 10, 372. http://doi.org/10.3389/fnins.2016.00372 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24896 | |
dc.description | A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml. | |
dc.description.abstract | The utilization of physical activity as a therapeutic tool is rapidly growing in the medical community and the role exercise may offer in the alleviation of painful disease states is an emerging research area. The development of neuropathic pain is a complex mechanism, which clinicians and researchers are continually working to better understand. The limited therapies available for alleviation of these pain states are still focused on pain abatement and as opposed to treating underlying mechanisms. The continued research into exercise and pain may address these underlying mechanisms, but the mechanisms which exercise acts through are still poorly understood. The objective of this review is to provide an overview of how the peripheral nervous system responds to exercise, the relationship of inflammation and exercise, and experimental and clinical use of exercise to treat pain. Although pain is associated with many conditions, this review highlights pain associated with diabetes as well as experimental studies on nerve damages-associated pain. Because of the global effects of exercise across multiple organ systems, exercise intervention can address multiple problems across the entire nervous system through a single intervention. This is a double-edged sword however, as the global interactions of exercise also require in depth investigations to include and identify the many changes that can occur after physical activity. A continued investment into research is necessary to advance the adoption of physical activity as a beneficial remedy for neuropathic pain. The following highlights our current understanding of how exercise alters pain, the varied pain models used to explore exercise intervention, and the molecular pathways leading to the physiological and pathological changes following exercise intervention. | en_US |
dc.publisher | Frontiers Media | en_US |
dc.rights | Copyright © 2016 Cooper, Kluding and Wright. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Exercise | en_US |
dc.subject | Pain management | en_US |
dc.subject | Neuropathy | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Neurotrophins | en_US |
dc.subject | Dorsal root ganglion | en_US |
dc.title | Emerging Relationships between Exercise, Sensory Nerves, and Neuropathic Pain | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Cooper, Michael A. | |
kusw.kuauthor | Wright, Douglas E. | |
kusw.kuauthor | Kluding, Patricia M. | |
kusw.kudepartment | Anatomy and Cell Biology | en_US |
kusw.kudepartment | Physical Therapy and Rehabilitation Science | en_US |
dc.identifier.doi | 10.3389/fnins.2016.00372 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-9312-0399 | |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC4993768 | en_US |
dc.rights.accessrights | openAccess |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as: Copyright © 2016 Cooper, Kluding and Wright. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the
original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.