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dc.contributor.authorKankanamalage, Anushka C. Galasiti
dc.contributor.authorRathnayake, Athri D.
dc.contributor.authorDamalanka, Vishnu C.
dc.contributor.authorWeerawarna, Pathum M.
dc.contributor.authorDoyle, Sean T.
dc.contributor.authorAlsoudi, Amer F.
dc.contributor.authorDissanayake, D. M. Padmasankha
dc.contributor.authorGroutas, William C.
dc.contributor.authorKim, Yunjeong
dc.contributor.authorChang, Kyeong-Ok
dc.contributor.authorLushington, Gerald H.
dc.contributor.authorMehzabeen, Nurjahan
dc.contributor.authorLovell, Scott
dc.contributor.authorBattaile, Kevin P.
dc.date.accessioned2017-08-30T16:40:39Z
dc.date.available2017-08-30T16:40:39Z
dc.date.issued2017-01-27
dc.identifier.citationGalasiti Kankanamalage, A. C., Kim, Y., Rathnayake, A. D., Damalanka, V. C., Weerawarna, P. M., Doyle, S. T., … Groutas, W. C. (2017). Structure-Based Exploration and Exploitation of the S4 Subsite of Norovirus 3CL Protease in the Design of Potent and Permeable Inhibitors. European Journal of Medicinal Chemistry, 126, 502–516. http://doi.org/10.1016/j.ejmech.2016.11.027en_US
dc.identifier.urihttp://hdl.handle.net/1808/24876
dc.description.abstractHuman noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised patients and children, constitute a serious public health concern. There are currently no approved human vaccines or norovirus-specific small-molecule therapeutics or prophylactics. Norovirus 3CL protease has recently emerged as a potential therapeutic target for the development of anti-norovirus agents. We hypothesized that the S4 subsite of the enzyme may provide an effective means of designing potent and cell permeable inhibitors of the enzyme. We report herein the structure-guided exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design and synthesis of effective inhibitors of the protease.en_US
dc.publisherElsevieren_US
dc.rights© 2017. This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) license.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.subjectNorovirusen_US
dc.subject3CL proteaseen_US
dc.subjectS4 subsiteen_US
dc.subjectOptimizationen_US
dc.titleStructure-Based Exploration and Exploitation of the S4 Subsite of Norovirus 3CL Protease in the Design of Potent and Permeable Inhibitorsen_US
dc.typeArticleen_US
kusw.kuauthorMehzabeen, Nurjahan
kusw.kuauthorLovell, Scott
kusw.kudepartmentProtein Structure Laboratoryen_US
dc.identifier.doi10.1016/j.ejmech.2016.11.027en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC5501333en_US
dc.rights.accessrightsopenAccess


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© 2017. This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) license.
Except where otherwise noted, this item's license is described as: © 2017. This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) license.