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    Hybrid antimalarials; the reaction of 8-amino-quinolines with nitrodiols

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    donahoe_1950_3427983.pdf (13.38Mb)
    Issue Date
    1950-05
    Author
    Donahoe, Hugh B.
    Publisher
    University of Kansas
    Type
    Dissertation
    Degree Level
    Ph.D.
    Discipline
    Chemistry
    Rights
    This work is in the public domain according to U.S. copyright law and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
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    Abstract
    Malaria is one of the oldest diseases known to man, and, even today, with the great advances in medical science, it affects a large percentage of the human race. It has been estimated that.the disease attacks several hundred million people every year and that it accounts for three million.fatalities in the same period of time. Approximately twenty•five per cent of the hospital admissions among United States troops stationed at Vera Cruz in the Mexican war was due to malaria and there were 1,213,685 cases among the white troops on the Union side during the Civil War. The disease prevented action by both Allied and Central Powers in the Near East in World War I, and it has been reported that the incidence of malaria in the Pacific reached 750 per thousand per annum in the early years of the Second World War. In the United States, which is in a temperate zone, an estimated one million persons are infected and it has been found in every state in the Union. A never-ending search for more potent and less toxic antimalarials has continued and will undoubtedly do so until this scourge is no longer of importance.
    Description
    Thesis (Ph. D.)--University of Kansas, Chemistry, 1950.
    URI
    http://hdl.handle.net/1808/24716
    Collections
    • Chemistry Dissertations and Theses [336]
    • Dissertations [4472]

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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