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dc.contributor.authorRice, Mabel L.
dc.contributor.authorZeldow, Bret
dc.contributor.authorSiberry, George K.
dc.contributor.authorPurswani, Murli U.
dc.contributor.authorMalee, Kathleen
dc.contributor.authorHoffman, Howard J.
dc.contributor.authorFrederick, Toni
dc.contributor.authorBuchanan, Ashley L.
dc.contributor.authorSirois, Patricia A.
dc.contributor.authorAllison, Susannah M.
dc.contributor.authorWilliams, Paige L.
dc.identifier.citationRice, M. L., Zeldow, B., Siberry, G. K., Purswani, M., Malee, K., Hoffman, H. J., … Pediatric HIV/AIDS Cohort Study (PHACS). (2013). Evaluation of Risk for Late Language Emergence after In Utero Antiretroviral Drug Exposure in HIV-exposed Uninfected Infants. The Pediatric Infectious Disease Journal, 32(10), e406–e413.
dc.descriptionThis is not the published version.en_US
dc.description.abstractBACKGROUND Combination antiretroviral (cARV) regimens are recommended for pregnant women with HIV to prevent perinatal HIV transmission. Safety is a concern for infants who were HIV-exposed but uninfected (HEU), particularly for neurodevelopmental problems, such as language delays. METHODS We studied late language emergence (LLE) in HEU children enrolled in a US-based prospective cohort study. LLE was defined as a caregiver-reported score ≤ 10th percentile in any of 4 domains of the MacArthur-Bates Communicative Development Inventory for one-year-olds and as ≥1 standard deviation below age-specific norms for the Ages and Stages Questionnaire for two-year-olds. Logistic regression models were used to evaluate associations of in utero cARV exposure with LLE, adjusting for infant, maternal, and environmental characteristics. RESULTS 1,129 language assessments were conducted among 792 one- and two-year-olds (50% male, 62% black, and 37% Hispanic). Overall, 86% had in utero exposure to cARV and 83% to protease inhibitors. LLE was identified in 26% of one-year-olds and 23% of two-year-olds, with higher rates among boys. In adjusted models, LLE was not associated with maternal cARV or ARV drug classes in either age group. Among cARV-exposed one-year-olds, increased odds of LLE was observed for those exposed to atazanavir (aOR=1.83, 95% CI=1.10-3.04), particularly after the first trimester (aOR=3.56, p=0.001), compared to atazanavir-unexposed infants. No associations of individual ARV drugs with LLE were observed among two-year-olds. CONCLUSIONS In utero cARV exposure showed little association with LLE, except for a higher risk of language delay observed in one-year-old infants with atazanavir exposure.en_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.subjectHIV-exposed infantsen_US
dc.subjectCohort studyen_US
dc.subjectLanguage delayen_US
dc.titleEvaluation of Risk for Late Language Emergence after In Utero Antiretroviral Drug Exposure in HIV-exposed Uninfected Infantsen_US
kusw.kuauthorRice, Mabel L.
kusw.oanotesPer SHERPA/RoMEO 6/27/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: grey tick subject to Restrictions below, author can archive post-print (ie final draft post-refereeing) Restrictions:

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kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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