Target Nanodiamonds as Phenotype Specific Photoacoustic Contrast Agents for Breast Cancer
dc.contributor.author | Zhang, Ti | |
dc.contributor.author | Cui, Huizhong | |
dc.contributor.author | Fang, Chia-Yi | |
dc.contributor.author | Cheng, Kun | |
dc.contributor.author | Chang, Huan-Cheng | |
dc.contributor.author | Forrest, M. Laird | |
dc.date.accessioned | 2017-06-27T16:31:44Z | |
dc.date.available | 2017-06-27T16:31:44Z | |
dc.date.issued | 2015-03 | |
dc.identifier.citation | Zhang, T., Cui, H., Fang, C.-Y., Cheng, K., Yang, X., Chang, H.-C., & Forrest, M. L. (2015). Targeted Nanodiamonds as Phenotype Specific Photoacoustic Contrast Agents for Breast Cancer. Nanomedicine (London, England), 10(4), 573–587. http://doi.org/10.2217/nnm.14.141 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24643 | |
dc.description.abstract | AIM: The aim is to develop irradiated nanodiamonds (INDs) as a molecularly-targeted contrast agent for high resolution and phenotype-specific detection of breast cancer with photoacoustic (PA) imaging. MATERIALS & METHODS: The surface of acid treated radiation-damaged nanodiamonds was grafted with polyethylene glycol (PEG) to improve its stability and circulation time in blood, followed by conjugation to an anti-Human epidermal growth factor receptor-2 (HER2) peptide (KCCYSL) with a final nanoparticle size of ca. 92 nm. Immunocompetent mice bearing orthotopic HER2 positive or negative tumors were administered INDs and PA imaged using an 820-nm near infrared laser. RESULTS: PA images demonstrated that INDs accumulate in tumors and completely delineated the entire tumor within 10 hours. HER2 targeting significantly enhanced imaging of HER2-positive tumors. Pathological examination demonstrated INDs are non-toxic. CONCLUSIONS: PA technology is adaptable to low-cost bedside medicine, and with new contrast agents described herein, PA can achieve high resolution (sub-mm) and phenotype specific monitoring of cancer growth. | en_US |
dc.publisher | Future Medicine | en_US |
dc.subject | Nanodiamond | en_US |
dc.subject | Photoacoustic Imaging | en_US |
dc.subject | Contrast agent | en_US |
dc.subject | Breast Cancer | en_US |
dc.subject | HER2 | en_US |
dc.title | Target Nanodiamonds as Phenotype Specific Photoacoustic Contrast Agents for Breast Cancer | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Zhang, Ti | |
kusw.kuauthor | Cui, Huizhong | |
kusw.kuauthor | Yang, Xinmai | |
kusw.kuauthor | Forrest, M. Laird | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
dc.identifier.doi | 10.2217/nnm.14.141 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC4703108 | en_US |
dc.rights.accessrights | openAccess |