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dc.contributor.authorChoi, In-Young
dc.contributor.authorLee, S.-P.
dc.contributor.authorDenney, Douglas R.
dc.contributor.authorLynch, Sharon G.
dc.identifier.citationChoi, I.-Y., Lee, S.-P., Denney, D. R., & Lynch, S. G. (2011). Lower Levels of Glutathione (GSH) in the Brains of Secondary Progressive Multiple Sclerosis Patients Measured by 1H Magnetic Resonance Chemical Shift Imaging at 3 T. Multiple Sclerosis (Houndmills, Basingstoke, England), 17(3), 289–296.
dc.description.abstractBACKGROUND: Disability levels for patients with secondary progressive multiple sclerosis (SPMS) often worsen despite a stable MRI T2 lesion burden. The presence of oxidative stress in the absence of measurable inflammation could help explain this phenomenon. In this study, the assessment of an in vivo marker of oxidative stress, cerebral glutathione (GSH), using magnetic resonance chemical shift imaging (CSI) is described, and GSH levels were compared in patients with SPMS and healthy controls. OBJECTIVE: To assess whether GSH, a key antioxidant in the brain, is lower in the SPMS patients compared to matched controls. METHODS: Seventeen patients with SPMS (Expanded Disability Status Scale = 4.0–7.0; length of MS diagnosis = 19.4±7 years) and 17 age- and gender-matched healthy controls were studied. GSH levels were measured in the fronto-parietal regions of the brain using a specially designed magnetic resonance spectroscopy technique, CSI of GSH, at 3T. RESULTS: The levels of GSH were lower for SPMS patients than for controls, the largest reduction (18.5%) being in the frontal region (p=0.001). CONCLUSION: The lower GSH levels in these patients indicate the presence of oxidative stress in SPMS. This process could be at least partially responsible for ongoing functional decline in SPMS.en_US
dc.publisherSAGE Publicationsen_US
dc.subjectSecondary progressive multiple sclerosisen_US
dc.subjectOxidative stressen_US
dc.subjectHuman brainen_US
dc.subjectIn vivoen_US
dc.subjectMagnetic resonanceen_US
dc.subjectChemical shift imagingen_US
dc.titleLower Levels of Glutathione (GSH) in the Brains of Secondary Progressive Multiple Sclerosis Patients Measured by 1H Magnetic Resonance Chemical Shift Imaging at 3 Ten_US
kusw.kuauthorDenney, Douglas R.
kusw.oanotesPer SHERPA/RoMEO 6/23/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions:

Authors retain copyright Pre-print on any website Author's post-print on author's personal website, departmental website, institutional website or institutional repository On other repositories including PubMed Central after 12 months embargo Publisher copyright and source must be acknowledged Publisher's version/PDF cannot be used Post-print version with changes from referees comments can be used "as published" final version with layout and copy-editing changes cannot be archived but can be used on secure institutional intranet Must link to publisher version with DOI
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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