Abstract
Hsp90 C-terminal inhibitors are advantageous for the development of new cancer chemotherapeutics due to their ability to segregate client protein degradation from induction of the prosurvival heat shock response, which is a major detriment associated with Hsp90 N-terminal inhibitors under clinical investigation. Based upon prior SAR trends, a 1,2,3-triazole side chain was placed in lieu of the aryl side chain and attached to both the coumarin and biphenyl scaffold. Antiproliferative studies against SKBr3 and MCF-7 breast cancer cell lines demonstrated these triazole-containing compounds to exhibit improved activity. These compounds were shown to manifest Hsp90 inhibitory activity through Western blot analysis and represent a new scaffold upon which more potent inhibitors can be pursued.
Citation
Zhao, J., Zhao, H., Hall, J. A., Brown, D., Brandes, E., Bazzill, J., … Blagg, B. S. J. (2014). Triazole Containing Novobiocin and Biphenyl Amides as Hsp90 C-Terminal Inhibitors. MedChemComm, 5(9), 1317–1323. http://doi.org/10.1039/C4MD00102H