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dc.contributor.authorWright, Laura E.
dc.contributor.authorFrye, Jennifer B.
dc.contributor.authorTimmermann, Barbara N.
dc.contributor.authorFunk, Janet L.
dc.date.accessioned2017-06-14T21:21:04Z
dc.date.available2017-06-14T21:21:04Z
dc.date.issued2010-09-08
dc.identifier.citationWright, L. E., Frye, J. B., Timmermann, B. N., & Funk, J. L. (2010). Protection of Trabecular Bone in Ovariectomized Rats by Turmeric (Curcuma longa L.) is Dependent on Extract Composition. Journal of Agricultural and Food Chemistry, 58(17), 9498–9504. http://doi.org/10.1021/jf101873f.en_US
dc.identifier.urihttp://hdl.handle.net/1808/24506
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/jf101873f
dc.description.abstractExtracts prepared from turmeric (Curcuma longa L., [Zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis. Three-month female Sprague Dawley rats were ovariectomized (OVX) and treated with a chemically complex turmeric fraction (41% curcuminoids by weight) or a curcuminoid-enriched turmeric fraction (94% curcuminoids by weight), both dosed at 60mg/kg 3x per week, or vehicle alone. Effects of two months of treatment on OVX-induced bone loss were followed prospectively by serial assessment of bone mineral density (BMD) of the distal femur using dual-energy x-ray absorptiometry (DXA), while treatment effects on trabecular bone microarchitecture were assessed at two months by micro-computerized tomography (μCT). Chemically complex turmeric did not prevent bone loss, however, the curcuminoid-enriched turmeric prevented up to 50% of OVX-induced loss of trabecular bone and also preserved the number and connectedness of the strut-like trabeculae. These results suggest that turmeric may have bone-protective effects but that extract composition is a critical factor.en_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectTurmericen_US
dc.subjectCurcuma longa Len_US
dc.subjectCurcuminoidsen_US
dc.subjectOvariectomyen_US
dc.subjectBone mineral densityen_US
dc.subjectBone ìCTen_US
dc.titleProtection of Trabecular Bone in Ovariectomized Rats by Turmeric (Curcuma longa L.) is Dependent on Extract Compositionen_US
dc.typeArticleen_US
kusw.kuauthorWright, Laura E.
kusw.kuauthorFrye, Jennifer B.
kusw.kuauthorTimmermann, Barbara N.
kusw.kuauthorFunk, Janet L.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1021/jf101873fen_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC2945868en_US
dc.rights.accessrightsopenAccess


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