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Protection of Trabecular Bone in Ovariectomized Rats by Turmeric (Curcuma longa L.) is Dependent on Extract Composition
dc.contributor.author | Wright, Laura E. | |
dc.contributor.author | Frye, Jennifer B. | |
dc.contributor.author | Timmermann, Barbara N. | |
dc.contributor.author | Funk, Janet L. | |
dc.date.accessioned | 2017-06-14T21:21:04Z | |
dc.date.available | 2017-06-14T21:21:04Z | |
dc.date.issued | 2010-09-08 | |
dc.identifier.citation | Wright, L. E., Frye, J. B., Timmermann, B. N., & Funk, J. L. (2010). Protection of Trabecular Bone in Ovariectomized Rats by Turmeric (Curcuma longa L.) is Dependent on Extract Composition. Journal of Agricultural and Food Chemistry, 58(17), 9498–9504. http://doi.org/10.1021/jf101873f. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24506 | |
dc.description | This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of Agricultural and Food Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/jf101873f | |
dc.description.abstract | Extracts prepared from turmeric (Curcuma longa L., [Zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis. Three-month female Sprague Dawley rats were ovariectomized (OVX) and treated with a chemically complex turmeric fraction (41% curcuminoids by weight) or a curcuminoid-enriched turmeric fraction (94% curcuminoids by weight), both dosed at 60mg/kg 3x per week, or vehicle alone. Effects of two months of treatment on OVX-induced bone loss were followed prospectively by serial assessment of bone mineral density (BMD) of the distal femur using dual-energy x-ray absorptiometry (DXA), while treatment effects on trabecular bone microarchitecture were assessed at two months by micro-computerized tomography (μCT). Chemically complex turmeric did not prevent bone loss, however, the curcuminoid-enriched turmeric prevented up to 50% of OVX-induced loss of trabecular bone and also preserved the number and connectedness of the strut-like trabeculae. These results suggest that turmeric may have bone-protective effects but that extract composition is a critical factor. | en_US |
dc.publisher | American Chemical Society | en_US |
dc.subject | Turmeric | en_US |
dc.subject | Curcuma longa L | en_US |
dc.subject | Curcuminoids | en_US |
dc.subject | Ovariectomy | en_US |
dc.subject | Bone mineral density | en_US |
dc.subject | Bone ìCT | en_US |
dc.title | Protection of Trabecular Bone in Ovariectomized Rats by Turmeric (Curcuma longa L.) is Dependent on Extract Composition | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Wright, Laura E. | |
kusw.kuauthor | Frye, Jennifer B. | |
kusw.kuauthor | Timmermann, Barbara N. | |
kusw.kuauthor | Funk, Janet L. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1021/jf101873f | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC2945868 | en_US |
dc.rights.accessrights | openAccess |