KUKU

KU ScholarWorks

  • myKU
  • Email
  • Enroll & Pay
  • KU Directory
    • Login
    View Item 
    •   KU ScholarWorks
    • Ecology and Evolutionary Biology
    • Ecology and Evolutionary Biology Scholarly Works
    • View Item
    •   KU ScholarWorks
    • Ecology and Evolutionary Biology
    • Ecology and Evolutionary Biology Scholarly Works
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Resources, mortality, and disease ecology: Importance of positive feedbacks between host growth rate and pathogen dynamics

    Thumbnail
    View/Open
    Smith_2015.pdf (959.1Kb)
    Issue Date
    2015
    Author
    Smith, Val H.
    Holt, Robert D.
    Smith, Marilyn S.
    Niu, Yafen
    Barfield, Michael
    Publisher
    Taylor & Francis
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Metadata
    Show full item record
    Abstract
    Resource theory and metabolic scaling theory suggest that the dynamics of a pathogen within a host should strongly depend upon the rate of host cell metabolism. Once an infection occurs, key ecological interactions occur on or within the host organism that determine whether the pathogen dies out, persists as a chronic infection, or grows to densities that lead to host death. We hypothesize that, in general, conditions favoring rapid host growth rates should amplify the replication and proliferation of both fungal and viral pathogens. If a host population experiences an increase in mortality, to persist it must have a higher growth rate, per host, often reflecting greater resource availability per capita. We hypothesize that this could indirectly foster the pathogen, which also benefits from increased within-host resource turnover. We first bring together in a short review a number of key prior studies which illustrate resource effects on viral and fungal pathogen dynamics. We then report new results from a semi-continuous cell culture experiment with SHIV, demonstrating that higher mortality rates indeed can promote viral proliferation. We develop a simple model that illustrates dynamical consequences of these resource effects, including interesting effects such as alternative stable states and oscillatory dynamics. Our paper contributes to a growing body of literature at the interface of ecology and infectious disease epidemiology, emphasizing that host abundances alone do not drive community dynamics: the physiological state and resource content of infected hosts also strongly influence host-pathogen interactions.
    Description
    This is an Accepted Manuscript of an article published by Taylor & Francis in Israel Journal of Ecology and Evolution in 2015, available online: http://www.tandfonline.com/10.1080/15659801.2015.1035508.
    URI
    http://hdl.handle.net/1808/24500
    DOI
    https://doi.org/10.1080/15659801.2015.1035508
    Collections
    • Ecology and Evolutionary Biology Scholarly Works [1450]
    Citation
    Smith, V. H., Holt, R. D., Smith, M. S., Niu, Y., & Barfield, M. (2015). Resources, mortality, and disease ecology: Importance of positive feedbacks between host growth rate and pathogen dynamics. Israel Journal of Ecology & Evolution, 61(1), 37–49. http://doi.org/10.1080/15659801.2015.1035508

    Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.


    We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.


    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    Browse

    All of KU ScholarWorksCommunities & CollectionsThis Collection

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    The University of Kansas
      Contact KU ScholarWorks
    Lawrence, KS | Maps
     
    • Academics
    • Admission
    • Alumni
    • Athletics
    • Campuses
    • Giving
    • Jobs

    The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University’s programs and activities. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA@ku.edu, 1246 W. Campus Road, Room 153A, Lawrence, KS, 66045, (785)864-6414, 711 TTY.

     Contact KU
    Lawrence, KS | Maps