KUKU

KU ScholarWorks

  • myKU
  • Email
  • Enroll & Pay
  • KU Directory
    • Login
    View Item 
    •   KU ScholarWorks
    • Pharmacy, School of
    • Pharmacy Scholarly Works
    • View Item
    •   KU ScholarWorks
    • Pharmacy, School of
    • Pharmacy Scholarly Works
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Plasma methionine sulfoxide in persons with familial Alzheimer’s disease mutations

    Thumbnail
    View/Open
    Moskovitz_2012.pdf (952.7Kb)
    Issue Date
    2012
    Author
    Ringman, John M.
    Fithian, Andrew T.
    Gylys, Karen
    Cummings, Jeffrey L.
    Coppola, Giovanni
    Elashoff, David
    Pratico, Domenico
    Moskovitz, Jackob
    Bitan, Gal
    Publisher
    Karger Publishers
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Metadata
    Show full item record
    Abstract
    BACKGROUND: Convergent evidence suggests that oxidative stress plays a central role in the pathology of Alzheimer’s disease (AD). We asked if consequently, oxidation of methionine residues to methionine sulfoxide (MetO) increased in plasma proteins of persons carrying familial AD (FAD) mutations. METHODS: Plasma was collected from 31 persons from families harboring PSEN1 or APP mutations. Using Western blot analysis with a novel anti-MetO polyclonal antibody, MetO levels were measured and compared between FAD mutation carriers (MCs) and non-mutation carrying (NCs) kin. RESULTS: A MetO-positive 120 kDa gel band distinguished FAD MCs and NCs (mean 11.4 ± 2.8 vs. 4.0 ± 3.1, p = 0.02). In a subset of subjects for whom both measurements were available, MetO levels correlated well with plasma F2-isoprostane (r = 0.81, p < 0.001) and superoxide dismutase 1 (r = 0.52, p = 0.004) levels. CONCLUSIONS: Our data provide evidence for elevated MetO levels in persons carrying FAD mutations that correlate with other indices of oxidative stress and suggest that plasma oxidative stress markers may be useful for diagnosis of AD.
    Description
    The final, published version of this article is available at http://www.karger.com/?doi=10.1159/000338546.
    URI
    http://hdl.handle.net/1808/24461
    DOI
    https://doi.org/10.1159/000338546
    Collections
    • Pharmacy Scholarly Works [286]
    Citation
    Ringman, J. M., Fithian, A. T., Gylys, K., Cummings, J. L., Coppola, G., Elashoff, D., … Bitan, G. (2012). Plasma methionine sulfoxide in persons with familial Alzheimer’s disease mutations. Dementia and Geriatric Cognitive Disorders, 33(4), 219–225. http://doi.org/10.1159/000338546

    Items in KU ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.


    We want to hear from you! Please share your stories about how Open Access to this item benefits YOU.


    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    Browse

    All of KU ScholarWorksCommunities & CollectionsThis Collection

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

    The University of Kansas
      Contact KU ScholarWorks
    Lawrence, KS | Maps
     
    • Academics
    • Admission
    • Alumni
    • Athletics
    • Campuses
    • Giving
    • Jobs

    The University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University’s programs and activities. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA@ku.edu, 1246 W. Campus Road, Room 153A, Lawrence, KS, 66045, (785)864-6414, 711 TTY.

     Contact KU
    Lawrence, KS | Maps