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    Open Access High Throughput Drug Discovery in the Public Domain: A Mount Everest in the Making

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    Roy_2010.pdf (1.915Mb)
    Issue Date
    2010-11-11
    Author
    Roy, Anuradha
    McDonald, Peter R.
    Sittampalam, Sitta
    Chaguturu, Rathnam
    Publisher
    Bentham Science Publishers
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Published Version
    http://www.eurekaselect.com/72441
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    Abstract
    High throughput screening (HTS) facilitates screening large numbers of compounds against a biochemical target of interest using validated biological or biophysical assays. In recent years, a significant number of drugs in clinical trails originated from HTS campaigns, validating HTS as a bona fide mechanism for hit finding. In the current drug discovery landscape, the pharmaceutical industry is embracing open innovation strategies with academia to maximize their research capabilities and to feed their drug discovery pipeline. The goals of academic research have therefore expanded from target identification and validation to probe discovery, chemical genomics, and compound library screening. This trend is reflected in the emergence of HTS centers in the public domain over the past decade, ranging in size from modestly equipped academic screening centers to well endowed Molecular Libraries Probe Centers Network (MLPCN) centers funded by the NIH Roadmap initiative. These centers facilitate a comprehensive approach to probe discovery in academia and utilize both classical and cutting-edge assay technologies for executing primary and secondary screening campaigns. The various facets of academic HTS centers as well as their implications on technology transfer and drug discovery are discussed, and a roadmap for successful drug discovery in the public domain is presented. New lead discovery against therapeutic targets, especially those involving the rare and neglected diseases, is indeed a Mount Everestonian size task, and requires diligent implementation of pharmaceutical industry’s best practices for a successful outcome.
    URI
    http://hdl.handle.net/1808/24449
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    • High Throughput Screening Laboratory Scholarly Works [14]
    Citation
    Roy, A., McDonald, P. R., Sittampalam, S., & Chaguturu, R. (2010). Open Access High Throughput Drug Discovery in the Public Domain: A Mount Everest in the Making. Current Pharmaceutical Biotechnology, 11(7), 764–778.

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    KU Libraries
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    785-864-8983

    KU Libraries
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    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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