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Prevalence and correlates of cognitive impairment in kidney transplant recipients
dc.contributor.author | Gupta, Aditi | |
dc.contributor.author | Mahnken, Jonathan D. | |
dc.contributor.author | Johnson, David K. | |
dc.contributor.author | Thomas, Tashra | |
dc.contributor.author | Subramaniam, Dipti | |
dc.contributor.author | Polshak, Tyler | |
dc.contributor.author | Gani, Imran | |
dc.contributor.author | Chen, G. John | |
dc.contributor.author | Burns, Jeffrey M. | |
dc.contributor.author | Sarnak, Mark J. | |
dc.date.accessioned | 2017-06-07T16:24:51Z | |
dc.date.available | 2017-06-07T16:24:51Z | |
dc.date.issued | 2017-05-12 | |
dc.identifier.citation | Gupta, A., Mahnken, J. D., Johnson, D. K., Thomas, T. S., Subramaniam, D., Polshak, T., … Sarnak, M. J. (2017). Prevalence and correlates of cognitive impairment in kidney transplant recipients. BMC Nephrology, 18, 158. http://doi.org/10.1186/s12882-017-0570-1 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24404 | |
dc.description.abstract | BACKGROUND: There is a high prevalence of cognitive impairment in dialysis patients. The prevalence of cognitive impairment after kidney transplantation is unknown. METHODS: Study Design: Cross-sectional study. Setting and Participants: Single center study of prevalent kidney transplant recipients from a transplant clinic in a large academic center. Intervention: Assessment of cognition using the Montreal Cognitive Assessment (MoCA). Demographic and clinical variables associated with cognitive impairment were also examined. Outcomes and Measurements: a) Prevalence of cognitive impairment defined by a MoCA score of <26. b) Multivariable linear and logistic regression to examine the association of demographic and clinical factors with cognitive impairment. RESULTS: Data from 226 patients were analyzed. Mean (SD) age was 54 (13.4) years, 73% were white, 60% were male, 37% had diabetes, 58% had an education level of college or above, and the mean (SD) time since kidney transplant was 3.4 (4.1) years. The prevalence of cognitive impairment was 58.0%. Multivariable linear regression demonstrated that older age, male gender and absence of diabetes were associated with lower MoCA scores (p < 0.01 for all). Estimated glomerular filtration rate (eGFR) was not associated with level of cognition. The logistic regression analysis confirmed the association of older age with cognitive impairment. CONCLUSION: Cognitive impairment is common in prevalent kidney transplant recipients, at a younger age compared to general population, and is associated with certain demographic variables, but not level of eGFR. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12882-017-0570-1) contains supplementary material, which is available to authorized users. | en_US |
dc.publisher | BioMed Central | en_US |
dc.rights | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Kidney transplantation | en_US |
dc.subject | MoCA | en_US |
dc.subject | Cognitive impairment | en_US |
dc.title | Prevalence and correlates of cognitive impairment in kidney transplant recipients | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Johnson, David K. | |
kusw.kudepartment | Psychology | en_US |
dc.identifier.doi | 10.1186/s12882-017-0570-1 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC5429555 | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.