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dc.contributor.authorFranklin, Jade M.
dc.contributor.authorCarrasco, Gonzalo A.
dc.date.accessioned2017-06-06T20:24:47Z
dc.date.available2017-06-06T20:24:47Z
dc.date.issued2012-10
dc.identifier.citationFranklin, J. M., & Carrasco, G. A. (2012). Cannabinoid-Induced Enhanced Interaction and Protein Levels of Serotonin 5-HT2A and Dopamine D2 Receptors in Rat Prefrontal Cortex. Journal of Psychopharmacology (Oxford, England), 26(10), 1333–1347. http://doi.org/10.1177/0269881112450786en_US
dc.identifier.urihttp://hdl.handle.net/1808/24395
dc.description.abstractRecent evidence suggests that non-selective cannabinoid receptor agonists may regulate serotonin 2A (5-HT2A) receptor neurotransmission in brain. The molecular mechanisms of this regulation are unknown but could involve cannabinoid-induced enhanced interaction between 5-HT2A and dopamine D2 (D2) receptors. Here, we present experimental evidence that Sprague-Dawley rats treated with a non-selective cannabinoid receptor agonist (CP55,940, 50μg/kg, 7days, i.p.) showed enhanced co-immunoprecipitation of 5-HT2A and D2 receptors and enhanced membrane-associated expression of D2 and 5-HT2A receptors in prefrontal cortex (PFCx). Furthermore, 5-HT2A receptor mRNA levels were increased in PFCx suggesting a cannabinoid-induced upregulation of 5-HT2A receptors. To date, two cannabinoids receptors have been found in brain, CB1 and CB2 receptors. We used selective cannabinoid agonists in a neuronal cell line to study mechanisms that could mediate this 5-HT2A receptor upregulation. We found that selective CB2 receptor agonists upregulate 5-HT2A receptors by a mechanism that seems to involve activation of Gαi G-proteins, ERK1/2, and AP-1 transcription factor. We hypothesize that the enhanced cannabinoid-induced interaction between 5-HT2A and D2 receptors and in 5-HT2A and D2 receptors protein levels in the PFCx might provide a molecular mechanism by which activation of cannabinoid receptors might be contribute to the pathophysiology of some cognitive and mood disorders.en_US
dc.publisherSAGE Publicationsen_US
dc.subjectSerotoninen_US
dc.subjectPrefrontal cortexen_US
dc.subject5-HT2A receptoren_US
dc.subjectD2 receptoren_US
dc.subjectG proteinsen_US
dc.subjectCannabis sativaen_US
dc.titleCannabinoid-Induced Enhanced Interaction and Protein Levels of Serotonin 5-HT2A and Dopamine D2 Receptors in Rat Prefrontal Cortexen_US
dc.typeArticleen_US
kusw.kuauthorCarrasco, Gonzalo A.
kusw.kuauthorFranklin, Jade M.
kusw.kudepartmentPharmacyen_US
dc.identifier.doi10.1177/0269881112450786en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC3746962en_US
dc.rights.accessrightsopenAccess


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