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dc.contributor.authorSzostak, Michal
dc.contributor.authorYao, Lei
dc.contributor.authorDay, Victor W.
dc.contributor.authorPowell, Douglas R.
dc.contributor.authorAubé, Jeffrey
dc.identifier.citationSzostak, M., Yao, L., Day, V. W., Powell, D. R., & Aubé, J. (2010). Structural Characterization of N-Protonated Amides. Regioselective N-Activation of Medium-Bridged Twisted Lactams. Journal of the American Chemical Society, 132(26), 8836–8837.
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
dc.description.abstractThe straightforward protonation of lactams by treatment with acid and the full structural characterization of three resulting N-protonated lactams are disclosed. This work provides experimental evidence that N-protonation of amide bonds results in a dramatic increase of non-planarity about the C-N amide bond. The resulting compounds are discussed in structural, spectroscopic, and reactivity terms. The data suggests that ca. 50° distortion of these amide bonds suffices for their efficient N-activation.en_US
dc.publisherAmerican Chemical Societyen_US
dc.titleStructural Characterization of N-Protonated Amides. Regioselective N-Protonated Amides. Regioselective N-Activation of Medium-Bridged Twisted Lactamsen_US
kusw.kuauthorSzostak, Michal
kusw.kuauthorYao, Lei
kusw.kuauthorDay, Victor W.
kusw.kuauthorPowell, Douglas
kusw.kuauthorAubé, Jeffrey
kusw.oanotesPer SHERPA/RoMEO 6/6/2017: Author's Pre-print: grey tick subject to Restrictions below, author can archive pre-print (ie pre-refereeing) Restrictions:

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kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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