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dc.contributor.authorLee, Ji Hoon
dc.contributor.authorZhang, Qi
dc.contributor.authorJo, Sunhwan
dc.contributor.authorChai, Sergip
dc.contributor.authorOh, Misook
dc.contributor.authorIm, Wonpil
dc.contributor.authorLu, Hua
dc.contributor.authorLim, Hyun-Suk
dc.identifier.citationLee, J. H., Zhang, Q., Jo, S., Chai, S. C., Oh, M., Im, W., … Lim, H.-S. (2011). Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell-Permeable Inhibitors of Protein-Protein Interactions. Journal of the American Chemical Society, 133(4), 676–679.
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see
dc.description.abstractThere is considerable interest in developing nonpeptidic, small molecule α-helix mimetics to disrupt α-helix-mediated protein-protein interactions. Herein, we report the design of a novel pyrrolopyrimidine-based scaffold for such α-helix mimetics with increased conformational rigidity. We also developed a facile solid phase synthetic route, which is amenable to divergent synthesis of a large library. Using a fluorescence polarization-based assay, we identified cell permeable, dual MDMX/MDM2 inhibitors, demonstrating that the designed molecules can act as α-helix mimetics.en_US
dc.publisherAmerican Chemical Societyen_US
dc.titleNovel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell- Permeable Inhibitors of Protein-Protein Interactionsen_US
kusw.kuauthorJo, Sunhwan
kusw.kuauthorIm, Wonpil
kusw.kudepartmentMolecular Biosciencesen_US
kusw.oanotesPer SHERPA/RoMEO 6/6/2017: Author's Pre-print: grey tick subject to Restrictions below, author can archive pre-print (ie pre-refereeing) Restrictions:

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kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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