| dc.contributor.author | Lee, Ji Hoon | |
| dc.contributor.author | Zhang, Qi | |
| dc.contributor.author | Jo, Sunhwan | |
| dc.contributor.author | Chai, Sergip | |
| dc.contributor.author | Oh, Misook | |
| dc.contributor.author | Im, Wonpil | |
| dc.contributor.author | Lu, Hua | |
| dc.contributor.author | Lim, Hyun-Suk | |
| dc.date.accessioned | 2017-06-06T16:12:55Z | |
| dc.date.available | 2017-06-06T16:12:55Z | |
| dc.date.issued | 2011-02-02 | |
| dc.identifier.citation | Lee, J. H., Zhang, Q., Jo, S., Chai, S. C., Oh, M., Im, W., … Lim, H.-S. (2011). Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell-Permeable Inhibitors of Protein-Protein Interactions. Journal of the American Chemical Society, 133(4), 676–679. http://doi.org/10.1021/ja108230s | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/24380 | |
| dc.description | This document is the Accepted Manuscript version of a Published Work that appeared in final form in the Journal of the American Chemical Society, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/ja108230s. | en_US |
| dc.description.abstract | There is considerable interest in developing nonpeptidic, small molecule α-helix mimetics to disrupt α-helix-mediated protein-protein interactions. Herein, we report the design of a novel pyrrolopyrimidine-based scaffold for such α-helix mimetics with increased conformational rigidity. We also developed a facile solid phase synthetic route, which is amenable to divergent synthesis of a large library. Using a fluorescence polarization-based assay, we identified cell permeable, dual MDMX/MDM2 inhibitors, demonstrating that the designed molecules can act as α-helix mimetics. | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.title | Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell- Permeable Inhibitors of Protein-Protein Interactions | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Jo, Sunhwan | |
| kusw.kuauthor | Im, Wonpil | |
| kusw.kudepartment | Molecular Biosciences | en_US |
| kusw.oanotes | Per SHERPA/RoMEO 6/6/2017: Author's Pre-print: grey tick subject to Restrictions below, author can archive pre-print (ie pre-refereeing)
Restrictions: Must obtain written permission from Editor
Must not violate ACS ethical GuidelinesAuthor's Post-print: grey tick subject to Restrictions below, author can archive post-print (ie final draft post-refereeing)
Restrictions: If mandated by funding agency or employer/ institution
If mandated to deposit before 12 months, must obtain waiver from Institution/Funding agency or use AuthorChoice
12 months embargoPublisher's Version/PDF: cross author cannot archive publisher's version/PDF
General Conditions: On author's personal website, pre-print servers, institutional website, institutional repositories or subject repositories
Non-Commercial
Must be accompanied by set statement (see policy)
Must link to publisher version
Publisher's version/PDF cannot be used | en_US |
| dc.identifier.doi | 10.1021/ja108230s | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-4104-6473 | |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC3079198 | en_US |
| dc.rights.accessrights | openAccess | |
