Filing and Mining the Reactive Metabolite Target Protein Database
dc.contributor.author | Hanzlik, Robert P. | |
dc.contributor.author | Fang, Jianwen | |
dc.contributor.author | Koen, Yakov M. | |
dc.date.accessioned | 2017-06-01T16:11:35Z | |
dc.date.available | 2017-06-01T16:11:35Z | |
dc.date.issued | 2009-04-15 | |
dc.identifier.citation | Hanzlik, R. P., Fang, J., & Koen, Y. M. (2009). Filling and Mining the Reactive Metabolite Target Protein Database. Chemico-Biological Interactions, 179(1), 38–44. http://doi.org/10.1016/j.cbi.2008.08.016 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24330 | |
dc.description.abstract | The post-translational modification of proteins is a well-known endogenous mechanism for regulating protein function and activity. Cellular proteins are also susceptible to post-translational modification by xenobiotic agents that possess, or whose metabolites possess, significant electrophilic character. Such non-physiological modifications to endogenous proteins are sometimes benign, but in other cases they are strongly associated with, and are presumed to cause, lethal cytotoxic consequences via necrosis and/or apoptosis. The Reactive Metabolite Target Protein Database (TPDB) is a searchable, freely web-accessible (http://tpdb.medchem.ku.edu:8080/protein_database/) resource that attempts to provide a comprehensive, up-to-date listing of known reactive metabolite target proteins. In this report we characterize the TPDB by reviewing briefly how the information it contains came to be known. We also compare its information to that provided by other types of “-omics” studies relevant to toxicology, and we illustrate how bioinformatic analysis of target proteins may help to elucidate mechanisms of cytotoxic responses to reactive metabolites. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.title | Filing and Mining the Reactive Metabolite Target Protein Database | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Hanzlik, Robert P. | |
kusw.kuauthor | Fang, Jianwen | |
kusw.kuauthor | Koen, Yakov M. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1016/j.cbi.2008.08.016 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC2669808 | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.