ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening
| dc.contributor.author | Negri, Ana | |
| dc.contributor.author | Rives, Marie-Laure | |
| dc.contributor.author | Caspers, Michael J. | |
| dc.contributor.author | Prisinzano, Thomas E. | |
| dc.contributor.author | Javitch, Jonathan A. | |
| dc.contributor.author | Filizola, Marta | |
| dc.date.accessioned | 2017-05-16T18:36:59Z | |
| dc.date.available | 2017-05-16T18:36:59Z | |
| dc.date.issued | 2013-03-25 | |
| dc.identifier.citation | Negri, A., Rives, M.-L., Caspers, M. J., Prisinzano, T. E., Javitch, J. A., & Filizola, M. (2013). Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening. Journal of Chemical Information and Modeling, 53(3), 521–526. http://doi.org/10.1021/ci400019t | en_US |
| dc.identifier.uri | http://hdl.handle.net/1808/24227 | |
| dc.description.abstract | Kappa-opioid (KOP) receptor agonists exhibit analgesic effects without activating reward pathways. In the search for non-addictive opioid therapeutics and novel chemical tools to study physiological functions regulated by the KOP receptor, we screened in silico its recently released inactive crystal structure. A selective novel KOP receptor agonist emerged as a notable result, and is proposed as a new chemotype for the study of the KOP receptor in the etiology of drug addiction, depression, and/or pain. | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Chemical Information and Modeling, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/ci400019t. | en_US |
| dc.title | Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening | en_US |
| dc.type | Article | en_US |
| kusw.kuauthor | Prisinzano, Thomas E. | |
| kusw.kudepartment | Medicinal Chemistry | en_US |
| dc.identifier.doi | 10.1021/ci400019t | en_US |
| kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
| kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
| dc.identifier.pmid | PMC3702663 | en_US |
| dc.rights.accessrights | openAccess |
