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dc.contributor.authorNegri, Ana
dc.contributor.authorRives, Marie-Laure
dc.contributor.authorCaspers, Michael J.
dc.contributor.authorPrisinzano, Thomas E.
dc.contributor.authorJavitch, Jonathan A.
dc.contributor.authorFilizola, Marta
dc.date.accessioned2017-05-16T18:36:59Z
dc.date.available2017-05-16T18:36:59Z
dc.date.issued2013-03-25
dc.identifier.citationNegri, A., Rives, M.-L., Caspers, M. J., Prisinzano, T. E., Javitch, J. A., & Filizola, M. (2013). Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening. Journal of Chemical Information and Modeling, 53(3), 521–526. http://doi.org/10.1021/ci400019ten_US
dc.identifier.urihttp://hdl.handle.net/1808/24227
dc.description.abstractKappa-opioid (KOP) receptor agonists exhibit analgesic effects without activating reward pathways. In the search for non-addictive opioid therapeutics and novel chemical tools to study physiological functions regulated by the KOP receptor, we screened in silico its recently released inactive crystal structure. A selective novel KOP receptor agonist emerged as a notable result, and is proposed as a new chemotype for the study of the KOP receptor in the etiology of drug addiction, depression, and/or pain.en_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Chemical Information and Modeling, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/ci400019t.en_US
dc.titleDiscovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screeningen_US
dc.typeArticleen_US
kusw.kuauthorPrisinzano, Thomas E.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1021/ci400019ten_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC3702663en_US
dc.rights.accessrightsopenAccess


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