dc.contributor.author | Oien, Derek B. | |
dc.contributor.author | Ortiz, Andrea Naomi | |
dc.contributor.author | Rittel, Alexander G. | |
dc.contributor.author | Dobrowsky, Rick T. | |
dc.contributor.author | Johnson, Michael A. | |
dc.contributor.author | Levant, Beth | |
dc.contributor.author | Fowler, Stephen C. | |
dc.contributor.author | Moskovitz, Jackob | |
dc.date.accessioned | 2017-05-16T16:24:55Z | |
dc.date.available | 2017-05-16T16:24:55Z | |
dc.date.issued | 2010-07 | |
dc.identifier.citation | Oien, D. B., Ortiz, A. N., Rittel, A. G., Dobrowsky, R. T., Johnson, M. A., Levant, B., … Moskovitz, J. (2010). Dopamine D2 receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse. Journal of Neurochemistry, 114(1), 51–61. http://doi.org/10.1111/j.1471-4159.2010.06721.x | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24222 | |
dc.description.abstract | Previous research suggests that brain oxidative stress and altered rodent locomotor behavior are linked. We observed bio-behavioral changes in methionine sulfoxide reductase A knockout mice associated with abnormal dopamine signaling. Compromised ability of these knockout mice to reduce methionine sulfoxide enhances accumulation of sulfoxides in proteins. We examined the dopamine D2-receptor function and expression, which has an atypical arrangement and quantity of methionine residues. Indeed, protein expression levels of dopamine D2-receptor were higher in knockout mice compared with wild-type. However, the binding of dopamine D2-receptor agonist was compromised in the same fractions of knockout mice. Coupling efficiency of dopamine D2-receptors to G-proteins was also significantly reduced in knockout mice, supporting the compromised agonist binding. Furthermore, pre-synaptic dopamine release in knockout striatal sections was less responsive than control sections to dopamine D2-receptor ligands. Behaviorally, the locomotor activity of knockout mice was less responsive to the inhibitory effect of quinpirole than wild-type mice. Involvement of specific methionine residue oxidation in the dopamine D2-receptor third intracellular loop is suggested by in vitro studies. We conclude that ablation of methionine sulfoxide reductase can affect dopamine signaling through altering dopamine D2-receptor physiology and may be related to symptoms associated with neurological disorders and diseases. | en_US |
dc.publisher | Wiley | en_US |
dc.rights | This is the peer reviewed version of the following article: Oien, D. B., Ortiz, A. N., Rittel, A. G., Dobrowsky, R. T., Johnson, M. A., Levant, B., Fowler, S. C. and Moskovitz, J. (2010), Dopamine D2 receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse. Journal of Neurochemistry, 114: 51–61. , which has been published in final form at http://doi.org/10.1111/j.1471-4159.2010.06721.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en_US |
dc.subject | Dopamine | en_US |
dc.subject | Dopamine receptor | en_US |
dc.subject | Locomotor activity | en_US |
dc.subject | Methionine oxidation | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | Post-translation modification | en_US |
dc.title | Dopamine D2 receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Oien, Derek B. | |
kusw.kuauthor | Ortiz, Andrea N. | |
kusw.kuauthor | Rittel, Alexander G. | |
kusw.kuauthor | Dobrowsky, Rick T. | |
kusw.kuauthor | Johnson, Michael A. | |
kusw.kuauthor | Fowler, Stephen C. | |
kusw.kuauthor | Moskovitz, Jackob | |
kusw.kudepartment | Pharmacy | en_US |
kusw.kudepartment | Chemistry | en_US |
kusw.oanotes | Per SHERPA/RoMEO 5/16/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing)
Author's Post-print: grey tick subject to Restrictions below, author can archive post-print (ie final draft post-refereeing)
Restrictions: 12 months embargoPublisher's Version/PDF: cross author cannot archive publisher's version/PDF
General Conditions: Some journals have separate policies, please check with each journal directly
On author's personal website, institutional repositories, arXiv, AgEcon, PhilPapers, PubMed Central, RePEc or Social Science Research Network
Author's pre-print may not be updated with Publisher's Version/PDF
Author's pre-print must acknowledge acceptance for publication
Non-Commercial
Publisher's version/PDF cannot be used
Publisher source must be acknowledged with citation
Must link to publisher version with set statement (see policy)
If OnlineOpen is available, BBSRC, EPSRC, MRC, NERC and STFC authors, may self-archive after 12 months | en_US |
dc.identifier.doi | 10.1111/j.1471-4159.2010.06721.x | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC2933736 | en_US |
dc.rights.accessrights | openAccess | |