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Methylphenidate Attenuates Rats' Preference for a Novel Spatial Stimulus Introduced into a Familiar Enviroment: Assessment Using a Force Plate Actometer
dc.contributor.author | Fowler, Stephen C. | |
dc.contributor.author | Zarcone, Troy J. | |
dc.contributor.author | Levant, Beth | |
dc.date.accessioned | 2017-05-16T15:03:15Z | |
dc.date.available | 2017-05-16T15:03:15Z | |
dc.date.issued | 2010-03-30 | |
dc.identifier.citation | Fowler, S. C., Zarcone, T. J., & Levant, B. (2010). METHYLPHENIDATE ATTENUATES RATS’ PREFERENCE FOR A NOVEL SPATIAL STIMULUS INTRODUCED INTO A FAMILIAR ENVIRONMENT: ASSESSMENT USING A FORCE PLATE ACTOMETER. Journal of Neuroscience Methods, 189(1), 36–43. http://doi.org/10.1016/j.jneumeth.2010.03.014 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24215 | |
dc.description.abstract | Methylphenidate is a psychostimulant widely used in the treatment of attention deficit hyperactivity disorder (ADHD). Here we report a novel paradigm that affords inferences about habituation and attention to a novel stimulus in a familiar environment in a single test session without prior training of the animals. The paradigm was used to assess the effects of methylphenidate (2.5 and 5.0 mg/kg, sc) in young adult, male, Long-Evans rats. Methylphenidate increased locomotor activity during the initial exposure to the test apparatus in a non-dose-related manner. However, upon introduction of a novel spatial stimulus (an alcove) in the familiar environment, methylphenidate-treatment resulted in dose-related increases in distance traveled and inhibition of long dwell times in the alcove, the latter behavior being characteristic of vehicle-treated rats’ response to the alcove condition. These results demonstrate the utility of this paradigm in the elucidation of the behavioral effects of a drug commonly used in the treatment of ADHD. Findings also suggest that species-typical response preferences in rats (e.g., refuge-seeking) may emerge in experimental settings that add spatial novelty to otherwise featureless test enclosures commonly used to assess locomotor activity. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.subject | Spatial stimulus | en_US |
dc.subject | Novelty | en_US |
dc.subject | Attention | en_US |
dc.subject | Actometer | en_US |
dc.subject | Methylphenidate | en_US |
dc.subject | Rat | en_US |
dc.title | Methylphenidate Attenuates Rats' Preference for a Novel Spatial Stimulus Introduced into a Familiar Enviroment: Assessment Using a Force Plate Actometer | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Fowler, Stephen C. | |
kusw.kuauthor | Zarcone, Troy J. | |
kusw.kuauthor | Levant, Beth | |
kusw.kudepartment | Pharmacy | en_US |
dc.identifier.doi | 10.1016/j.jneumeth.2010.03.014 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC2864804 | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.