Animal models of tic disorders: A translational perspective
dc.contributor.author | Godar, Sean C. | |
dc.contributor.author | Mosher, Laura J. | |
dc.contributor.author | Di Giovanni, Giuseppe | |
dc.contributor.author | Bortolato, Marco | |
dc.date.accessioned | 2017-05-12T17:56:59Z | |
dc.date.available | 2017-05-12T17:56:59Z | |
dc.date.issued | 2014-12-30 | |
dc.identifier.citation | Godar, S. C., Mosher, L. J., Di Giovanni, G., & Bortolato, M. (2014). Animal models of tic disorders: A translational perspective. Journal of Neuroscience Methods, 238, 54–69. http://doi.org/10.1016/j.jneumeth.2014.09.008 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24117 | |
dc.description.abstract | Tics are repetitive, sudden movements and/or vocalizations, typically enacted as maladaptive responses to intrusive premonitory urges. The most severe tic disorder, Tourette syndrome (TS), is a childhood-onset condition featuring multiple motor and at least one phonic tic for a duration longer than 1 year. The pharmacological treatment of TS is mainly based on antipsychotic agents; while these drugs are often effective in reducing tic severity and frequency, their therapeutic compliance is limited by serious motor and cognitive side effects.The identification of novel therapeutic targets and development of better treatments for tic disorders is conditional on the development of animal models with high translational validity. In addition, these experimental tools can prove extremely useful to test hypotheses on the etiology and neurobiological bases of TS and related conditions. In recent years, the translational value of these animal models has been enhanced, thanks to a significant re-organization of our conceptual framework of neuropsychiatric disorders, with a greater focus on endophenotypes and quantitative indices, rather than qualitative descriptors.Given the complex and multifactorial nature of TS and other tic disorders, the selection of animal models that can appropriately capture specific symptomatic aspects of these conditions can pose significant theoretical and methodological challenges. In this article, we will review the state of the art on the available animal models of tic disorders, based on genetic mutations, environmental interventions as well as pharmacological manipulations. Furthermore, we will outline emerging lines of translational research showing how some of these experimental preparations have led to significant progress in the identification of novel therapeutic targets for tic disorders. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
dc.subject | Tourette syndrome | en_US |
dc.subject | Tic disorders | en_US |
dc.subject | Animal models | en_US |
dc.subject | Dopamin | en_US |
dc.title | Animal models of tic disorders: A translational perspective | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Godar, Sean C. | |
kusw.kuauthor | Mosher, Laura J. | |
kusw.kuauthor | Bortolato, Marco | |
kusw.kudepartment | Pharmacy | en_US |
dc.identifier.doi | 10.1016/j.jneumeth.2014.09.008 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC4345166 | en_US |
dc.rights.accessrights | openAccess |
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Except where otherwise noted, this item's license is described as: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.