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Fluorination Enables a Ligand-Controlled Regiodivergent Palladium-Catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones
dc.contributor.author | Yang, Ming-Hsiu | |
dc.contributor.author | Orsi, Douglas L. | |
dc.contributor.author | Altman, Ryan A. | |
dc.date.accessioned | 2017-05-10T16:17:32Z | |
dc.date.available | 2017-05-10T16:17:32Z | |
dc.date.issued | 2015-02-16 | |
dc.identifier.citation | Yang, M., Orsi, D. L., & Altman, R. A. (2015). Fluorination Enables a Ligand-Controlled Regiodivergent Palladium-Catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones. Angewandte Chemie (International Ed. in English), 54(8), 2361–2365. http://doi.org/10.1002/anie.201410039 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/24062 | |
dc.description | This is the peer reviewed version of the following article: Yang, M., Orsi, D. L., & Altman, R. A. (2015). Fluorination Enables a Ligand-Controlled Regiodivergent Palladium-Catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones. Angewandte Chemie (International Ed. in English), 54(8), 2361–2365. http://doi.org/10.1002/anie.201410039, which has been published in final form at doi.org/10.1002/anie.201410039. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | en_US |
dc.description.abstract | α,α-Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. In order to access the α-allyl-α,α-difluoroketone substructure, complementary Pd-catalyzed decarboxylative allylation reactions were developed to provide linear and branched α-allyl-α,α-difluoroketones. For these orthogonal processes, the regioselectivity was uniquely controlled by fluorination of the substrate and the structure of ligand. | en_US |
dc.publisher | Wiley | en_US |
dc.rights | © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | en_US |
dc.subject | Allylation | en_US |
dc.subject | Regioselectivity | en_US |
dc.subject | Synthetic methods | en_US |
dc.subject | P ligands | en_US |
dc.subject | Palladium | en_US |
dc.title | Fluorination Enables a Ligand-Controlled Regiodivergent Palladium-Catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Yang, Ming-Hsiu | |
kusw.kuauthor | Orsi, Douglas L. | |
kusw.kuauthor | Altman, Ryan A. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1002/anie.201410039 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC4373536 | en_US |
dc.rights.accessrights | openAccess |