Show simple item record

dc.contributor.authorQuinn, Kieran
dc.contributor.authorHenriques, Melanie
dc.contributor.authorTabuchi, Arata
dc.contributor.authorHan, Bing
dc.contributor.authorYang, Hong
dc.contributor.authorCheng, Wei-Erh
dc.contributor.authorTole, Soumitra
dc.contributor.authorYu, Hanpo
dc.contributor.authorLuo, Alice
dc.contributor.authorCharbonney, Emmanuel
dc.contributor.authorTullis, Elizabeth
dc.contributor.authorLazarus, Alan
dc.contributor.authorRobinson, Lisa
dc.contributor.authorNi, Heyu
dc.contributor.authorPeterson, Blake R.
dc.contributor.authorKuebler, Wolfgang
dc.contributor.authorSlutsky, Arthur
dc.contributor.authorZhang, Haibo
dc.date.accessioned2017-05-09T17:19:45Z
dc.date.available2017-05-09T17:19:45Z
dc.date.issued2011-09
dc.identifier.citationQuinn, K. L., Henriques, M., Tabuchi, A., Han, B., Yang, H., Cheng, W.-E., … Zhang, H. (2011). Human Neutrophil Peptides Mediate Endothelial-Monocyte Interaction, Foam Cell Formation, and Platelet Activation. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(9), 2070–2079. http://doi.org/10.1161/ATVBAHA.111.227116en_US
dc.identifier.urihttp://hdl.handle.net/1808/24042
dc.description.abstractObjective—Neutrophils are involved in the inflammatory responses during atherosclerosis. Human neutrophil peptides (HNPs) released from activated neutrophils exert immune modulating properties. We hypothesized that HNPs play an important role in neutrophil-mediated inflammatory cardiovascular responses in atherosclerosis. Methods and Results—We examined the role of HNPs in endothelial-leukocyte interaction, platelet activation, and foam cell formation in vitro and in vivo. We demonstrated that stimulation of human coronary artery endothelial cells with clinically relevant concentrations of HNPs resulted in monocyte adhesion and transmigration; induction of oxidative stress in human macrophages, which accelerates foam cell formation; and activation and aggregation of human platelets. The administration of superoxide dismutase or anti-CD36 antibody reduced foam cell formation and cholesterol efflux. Mice deficient in double genes of low-density lipoprotein receptor and low-density lipoprotein receptor–related protein (LRP), and mice deficient in a single gene of LRP8, the only LRP phenotype expressed in platelets, showed reduced leukocyte rolling and decreased platelet aggregation and thrombus formation in response to HNP stimulation. Conclusion—HNPs exert proatherosclerotic properties that appear to be mediated through LRP8 signaling pathways, suggesting an important role for HNPs in the development of inflammatory cardiovascular diseases.en_US
dc.publisherAmerican Heart Associationen_US
dc.rights© 2011 American Heart Association, Incen_US
dc.subjectAtherosclerosisen_US
dc.subjectLeukocytesen_US
dc.subjectTransgenic modelsen_US
dc.titleHuman Neutrophil Peptides Mediate Endothelial-Monocyte Interaction, Foam Cell Formation, and Platelet Activationen_US
dc.typeArticleen_US
kusw.kuauthorPeterson, Blake
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1161/ATVBAHA.111.227116en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4909471en_US
dc.rights.accessrightsopenAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record