dc.contributor.author | Mays, Jared R. | |
dc.contributor.author | Hill, Stephanie A. | |
dc.contributor.author | Moyers, Justin T. | |
dc.contributor.author | Blagg, Brian S. J. | |
dc.date.accessioned | 2017-05-04T20:00:49Z | |
dc.date.available | 2017-05-04T20:00:49Z | |
dc.date.issued | 2010-01-01 | |
dc.identifier.citation | Mays, J. R., Hill, S. A., Moyers, J. T., & Blagg, B. S. J. (2010). The Synthesis and Evaluation of Flavone and Isoflavone Chimeras of Novobiocin and Derrubone. Bioorganic & Medicinal Chemistry, 18(1), 249. http://doi.org/10.1016/j.bmc.2009.10.061 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/23899 | |
dc.description.abstract | The natural products novobiocin and derrubone have both demonstrated Hsp90 inhibition and structure–activity relationships have been established for each scaffold. Given these compounds share several key structural features, we hypothesized that incorporation of elements from each could provide insight to structural features important for Hsp90 inhibition. Thus, chimeric analogues of novobiocin and derrubone were constructed and evaluated. These studies confirmed that the functionality present at the 3-position of the isoflavone plays a critical role in determining Hsp90 inhibition and suggests that the bicyclic ring system present in both novobiocin and derrubone do not share similar modes of binding. | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License. | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/3.0/us/ | en_US |
dc.subject | Hsp90 | en_US |
dc.subject | Novobiocin | en_US |
dc.subject | Derrubone | en_US |
dc.subject | Anticancer | en_US |
dc.title | The Synthesis and Evaluation of Flavone and Isoflavone Chimeras of Novobiocin and Derrubone | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Mays, Jared R. | |
kusw.kuauthor | Hill, Stephanie A. | |
kusw.kuauthor | Moyers, Justin T. | |
kusw.kuauthor | Blagg, Brian S. J. | |
kusw.kudepartment | Medicinal Chemistry | en_US |
dc.identifier.doi | 10.1016/j.bmc.2009.10.061 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC2818389 | en_US |
dc.rights.accessrights | openAccess | |