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dc.contributor.authorMays, Jared R.
dc.contributor.authorHill, Stephanie A.
dc.contributor.authorMoyers, Justin T.
dc.contributor.authorBlagg, Brian S. J.
dc.date.accessioned2017-05-04T20:00:49Z
dc.date.available2017-05-04T20:00:49Z
dc.date.issued2010-01-01
dc.identifier.citationMays, J. R., Hill, S. A., Moyers, J. T., & Blagg, B. S. J. (2010). The Synthesis and Evaluation of Flavone and Isoflavone Chimeras of Novobiocin and Derrubone. Bioorganic & Medicinal Chemistry, 18(1), 249. http://doi.org/10.1016/j.bmc.2009.10.061en_US
dc.identifier.urihttp://hdl.handle.net/1808/23899
dc.description.abstractThe natural products novobiocin and derrubone have both demonstrated Hsp90 inhibition and structure–activity relationships have been established for each scaffold. Given these compounds share several key structural features, we hypothesized that incorporation of elements from each could provide insight to structural features important for Hsp90 inhibition. Thus, chimeric analogues of novobiocin and derrubone were constructed and evaluated. These studies confirmed that the functionality present at the 3-position of the isoflavone plays a critical role in determining Hsp90 inhibition and suggests that the bicyclic ring system present in both novobiocin and derrubone do not share similar modes of binding.en_US
dc.publisherElsevieren_US
dc.rightsThis article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/us/en_US
dc.subjectHsp90en_US
dc.subjectNovobiocinen_US
dc.subjectDerruboneen_US
dc.subjectAnticanceren_US
dc.titleThe Synthesis and Evaluation of Flavone and Isoflavone Chimeras of Novobiocin and Derruboneen_US
dc.typeArticleen_US
kusw.kuauthorMays, Jared R.
kusw.kuauthorHill, Stephanie A.
kusw.kuauthorMoyers, Justin T.
kusw.kuauthorBlagg, Brian S. J.
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1016/j.bmc.2009.10.061en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC2818389en_US
dc.rights.accessrightsopenAccess


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This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License.
Except where otherwise noted, this item's license is described as: This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License.