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dc.contributor.authorHendricks, J. Adam
dc.contributor.authorHanson, Robert N.
dc.contributor.authorAmolins, Michael Wayne
dc.contributor.authorMihelcic, John M.
dc.contributor.authorBlagg, Brian S. J.
dc.date.accessioned2017-05-04T18:48:09Z
dc.date.available2017-05-04T18:48:09Z
dc.date.issued2013-06-15
dc.identifier.citationHendricks, J. A., Hanson, R. N., Amolins, M., Mihelcic, J. M., & Blagg, B. S. (2013). Synthesis and Preliminary Evaluation Steroidal Antiestrogen-Geldanamycin Conjugates. Bioorganic & Medicinal Chemistry Letters, 23(12), 3635–3639. http://doi.org/10.1016/j.bmcl.2013.03.116en_US
dc.identifier.urihttp://hdl.handle.net/1808/23894
dc.description.abstractThree novel steroidal antiestrogen-geldanamycin conjugates were prepared using a convergent strategy. The antiestrogenic component utilized the 11β-(4-functionalized-oxyphenyl) estradiol scaffold, while the geldanamycin component was derived by replacement of the 17-methoxy group with an appropriately functionalized amine. Ligation was achieved in high yield using azide alkyne cyclization reactions. Evaluation of the products against two breast cancer cell lines indicated that the conjugates retained significant antiproliferative activity.en_US
dc.publisherElsevieren_US
dc.rightsThis article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/us/en_US
dc.subjectAnti-estrogen geldanamycin conjugatesen_US
dc.subjectTargeted drug deliveryen_US
dc.subjectBreast canceren_US
dc.subjectClick chemistryen_US
dc.titleSynthesis and Preliminary Evaluation Steroidal AntiestrogenGeldanamycin Conjugatesen_US
dc.typeArticleen_US
kusw.kuauthorHendricks, J. Adam
kusw.kuauthorHanson, Robert N.
kusw.kuauthorAmolins, Michael
kusw.kuauthorMihelcic, John M.
kusw.kuauthorBlagg, Brian S. J.
kusw.kudepartmentChemistry and Chemical Biologyen_US
kusw.kudepartmentMedicinal Chemistryen_US
dc.identifier.doi10.1016/j.bmcl.2013.03.116en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC4123820en_US
dc.rights.accessrightsopenAccess


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This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License.
Except where otherwise noted, this item's license is described as: This article is made available under an Attribution-NonCommercial-NoDerivs 3.0 United States (CC BY-NC-ND 3.0 US) License.